英文名NF-kappaBeta activator 2 别名 3-[2-(2-fluoroanilino)-1,3-oxazol-5-yl]benzoic acid 产品名称 NF-kappa Beta 激活物2 分子结构 分子式 C16H11FN2O3 分子量 298.27 CAS 登录号 2375281-44-8 分子行输入简码SMILES C1=CC=C(C(=C1)NC2=NC=C(O2)C3=CC(=CC=C3)C(=O)O)F安全...
Moreover, a NF-kB inhibitor (PDTC) and an activator (TNF) were used before mechanical stretch. Realtime PCR and ELISA were performed to detect the mRNA and protein of IL-8, respectively. The results showed that the mechanical cyclic stretch led to increased Cyr61 expression at mRNA and ...
IKKβ functions as a principal upstream activator of the canonical NF-κB pathway by phosphorylating IκB, leading to its proteasomal degradation. Because IKKβ is considered a therapeutic target, understanding its regulation may facilitate the design of efficient regulators of this molecule. Here, we...
In this study, HepG2 cells were used to investigate the role of HSD17B4 in the proliferation of liver cancer cells treated with the NE-kappa B activator, tumor necrosis factor-alpha (TNE-alpha), with the inhibitor of NE-kappa B activation, pyrrolidinedithiocarbamate (PDTC), or with a ...
Here, we identify MKK7/JNKK2--a specific and essential activator of JNK--as a target of Gadd45 beta, and in fact, of NF-kappa B itself. Gadd45 beta binds to MKK7 directly and blocks its catalytic activity, thereby providing a molecular link between the NF-kappa B and JNK pathways. ...
Presents a study which investigated the influence of hyperoxia on the nitric oxide pathway in rat alveolar macrophages in vitro, its regulation by the transcription factors nuclear factor and activator protein. Effects of exposure to pure oxygen; Materials and methods used; Influence of antioxidants ...
and ADAMTS-4 in chondrocytes (100 μm). **p< 0.01 (compared with the model group). (ICH: Immunohistochemistry; COL2A1: type II collagen; MMPs: matrix metalloproteinases; ADAMTS-4: A disintegrin and metalloprotease with thrombospondin motifs-4; RANKL: receptor activator of nuclear factor-κB li...
SIRT1 activator (resveratrol) and inhibitor (EX527) were administered intraperitoneally 1 h after SAH induction. Twenty-four hours after SAH, the VSMC contractile phenotype marker alpha-smooth muscle actin (alpha-SMA) decreased, whereas the VSMC synthetic phenotype marker embryonic smooth muscle ...
Receptor activator of nf-κb ligand (rankl) activates tak1 mitogen-activated protein kinase kinase kinase through a signaling complex containing rank, tab2, and traf6. Mol. Cell. Biol. 2002, 22, 992–1000. [Google Scholar] [CrossRef] [PubMed] Franzoso, G.; Carlson, L.; Xing, L.; ...
LPS, an activator of inflammation, which can promote the secretion of pro-inflammatory cytokines, leading to a severe inflammatory response, is often used to induce inflammation in animal experiments [19]. Mon has been reported to possess anti-inflammatory effects as evidenced in various animal expe...