Wooten MW (1999) Function for NF-kB in neuronal survival: regulation by atypical protein kinase C. J Neurosci Res 58:607- 611.Wooten MW. Function for NF-kB in neuronal survival: regulation by atypical protein kinase C. J Neurosci Res 1999;58:607-11....
NF-kB 诱导激酶(NIK) 是激活非经典 NF-kB 通路所必需的,它调节免疫、发育和疾病的不同过程。 尽管最近的研究阐明了 NIK 在适应性免疫细胞和癌细胞代谢中的重要功能,但 NIK 在先天免疫细胞中代谢驱动的炎症反应中的作用仍不清楚。 在这项研究中,我们证明小鼠 NIK 缺陷的骨髓衍生巨噬细胞表现出线粒体依赖性代谢...
effector caspases, including mammalian caspase-3 and fly drICE/DCP-1, can function as repressors of NF-κB-mediated innate immune signalings. 宿主生物使用不同的先天免疫机制来抵御病原体感染,而严格控制先天免疫对于适当的免疫诱导和平衡至关重要。在此,我们报告了细胞凋亡诱导或caspase-3过表达导致人类细...
进一步地, 等胡认为肿瘤间质细胞如成纤维细胞中NF-KB的激活,可 以活化WNT 16B促进肿瘤细胞的存活和抵制化学放疗造成的肿瘤杀伤作用;此外,他们指出在乳腺肿瘤细胞中NF-KB的 激活,可以上调促炎性细胞因子IL-6的表达,进而促进肿瘤的生长;相反地,提到NF-KB信号通路的激活能够阻碍 肿瘤的生长,从而达到治疗肿瘤的目的;B...
中文名称NFKB激活蛋白抗体规格 别名NF-kappa-B-activating protein; Nkap; NKAP_HUMAN; Nuclear NF kappaB activating protein. 浓度1mg/1ml 规格0.2ml/200μg 抗体来源Rabbit 克隆类型polyclonal 交叉反应Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep ...
It was found that RIP2 activates NFkB pathway and up-regulates the anti-apoptotic ability of BNHL cells, providing experimental basis for its function in tumorigenesis and development. Keywords: RIP2, NFkB pathway, BNHL cells, anti-apoptosis 细胞凋亡是一种程序性的细胞死亡过程,对于维持组织稳态和...
function and activation of nf -kb in the immune system further annual reviews PA Baeuerle,T Henkel 被引量: 0发表: 0年 Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging the function of NF-kB system in the organization of defence ...
(Fig.3a). In addition to regulating genes through DNA methylation, CpG islands influence chromatin conformation. Accordingly, we found the CpG island embedded in a 3 kb region, which ENCODE ChIP sequencing (ChIP-seq) datasets also showed were enriched for numerous histone modifications. Based ...
NF—KB对TNF—a基因转录的调控及其与两型 TNF一Ⅸ生物学功能的相互影响 全文摘要 / f肿瘤坏死因子一a(tumor necrosis factor一Ⅸ,TNF—a)是一种具有 广泛生物学功能的细胞因子,其基因的表达受核因子一nB(nuclear factor-K)?rT-NF—KB)的调节。同时NF—KB又参与TNF一仪介导的生物学 作用。l本课题主要研究NF...
L. et al. Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity. Nat. Commun. 5, 5360 (2014). PubMed Google Scholar Chen, K. et al. Germline mutations in NFKB2 implicate the noncanonical NF-κB pathway in the pathogenesis ...