摘要: An of the article "Activation of NF-κB in CD8+ Dendritic Cells Ex Vivo by the γ134.5 Null Mutant Correlates with Immunity against Herpes Simplex Virus 1," by Huali Jin and colleagues is presented.年份: 2012 收藏 引用 批量引用...
CD8+ CD28- T SUPPRESSOR LYMPHOCYTES INHIBIT T HELPER INDUCED NF-kB ACTIVATION IN ANTIGEN PRESENTING CELLSAn abstract is unavailable. This article is available as a PDF only.doi:10.1097/00007890-200004271-01098Jianfeng LiZhuoru LiuAdriana I. Colovai...
2020). However, some studies have indicated the evidence for the activation of the circulating CD4+ and CD8+ T cells in COVID-19 patients (Chen and John Wherry 2020; Mathew et al. 2020). Abnormal activation of T cells followed by their depletion have been identified as the key course of...
A20 deficient T cells have enhanced NF-κB activation that promotes anti-tumour CD8+ T cell responses [16] and development of intrathymic Treg [17]. In spite of the expanded regulatory T cell pool, de-repression of NF-κB activation in these mice also results in increased numbers of ...
1. 2. 1 NF-κB 与非淋巴细胞造血作用 NF-κB 在 非淋巴细 胞造血作用中最重要的作用就是 CD8 - DCs 的发育需要,尽管单独敲除其他 NF-κB 基因对 DC 发育基因无影响,但同时敲除 p65 和 p50 对 DC 发育影响重大.因此,毫无疑问,DC 发育过程中必 须有 NF-κB[5].缺失 IKKβ 或用可穿透细胞膜的肽 ...
The inhibitor of kB kinase (IKK) is a central regulator of NF-kB signalling. Here the authors identify a motif conserved in substrates of canonical and alternative NF-kB pathways which mediates docking to catalytic IKK dimers: they show that phosphorylation of the conserved tyrosine suppresses the...
Regulatory T cells (Treg cells) act as a major rheostat regulating the strength of immune responses, enabling tolerance of harmless foreign antigens, and p
2A), specifically CD8 + T cells and NK cells. Taken together, these results may indicate a critical role for NF-κB signaling and NF-κB-specific mediators in potentiating cytotoxic activity and tumor regression in PD-1 blockade. All pathway and cell type score data can be found in ...
NF-κB activation supports tumorigenesis by enhancing cell proliferation and angiogenesis, inhibiting apoptosis, and promoting cell invasion and metastasis.4 There are 2 distinct but interacting arms of the NF-κB pathway: canonical (activated by tumor necrosis factor alpha [TNF-α], Toll-like ...
1, E and F). Taken together, our data suggest that Fas functions as a suppressor of spontaneous sarcoma and colon carcinoma. Download: Download high-res image (335KB) Download: Download full-size image FIGURE 1. Loss of Fas function increased spontaneous sarcoma and colon carcinoma development...