Although the neurofibromatoses have common characteristics, two distinct forms have been recognized based on clinical and genetic findings, neurofibromatosis type 1 (NF1), formerly known as von Recklinghausen's disease, and neurofibromatosis type 2 (NF2). Neurofibromatosis type 1 (NF1) is the most...
18. FDA Approves First Therapy for Children with Debilitating and Disfiguring Rare Disease,https://www.fda.gov/news-events/press-announcements/fda-approves-first-therapy-children-debilitating-and-disfiguring-rare-disease , accessed Aug 3rd, 20...
Nf-ya mRNA expression was induced in late stages of the disease in HD mouse models, presumably to compensate for the decreased levels of the functional protein; indeed, this is in accordance with a negative auto-regulatory transcriptional mechanism regulating Nf-y genes expression [135,136,137,...
Effect of renal disease on the standardized mortality ratio and life expectancy of patients with systemic lupus erythematosus. Arthritis Rheum. 2013;65(8):2154–60. Article CAS PubMed Google Scholar Zheng L, Sinniah R, Hsu SI. In situ glomerular expression of activated NF-kappaB in human ...
4 ⅐ No. 3 review Cardiovascular disease in neurofibromatosis 1: Report of the NF1 Cardiovascular Task Force J. M. Friedman, MD, PhD1, Jack Arbiser, MD3, Jonathan A. Epstein, MD4, David H. Gutmann, MD-PhD5, Stephen J. Huot, MD, PhD6, Angela E. Lin, MD7, Bruce McManus, MD...
Neurofibromatosis type 1 (NF1), also known as peripheral neurofibromatosis or von Recklinghausen disease, is an autosomal dominant genetic condition caused by a mutation in or a deletion of the NF1 gene. Only one copy of a mutated or deleted NF1 gene is required to affect an individual. Desc...
7 Therefore, considering that JXG is the most frequent tumor in NF1, it is probable that the coexistence of CaLS and JXGs in small children should not be considered a casual finding but rather one highly indicative of the disease. Their presence has also been associated with a greater risk ...
Pulmonary fibrosis is a progressive disease related to scarring in the lung tissue. As this occurs, a person's breathing becomes more difficult, eventually resulting in shortness of breath, even at rest. The leading cause of death in IPF patients was respiratory causes, followed by cancer. The...
- 《Cell Death & Disease》 被引量: 38发表: 2015年 Abstract 2273: c-Rel is a critical mediator of NF-κB-dependent apoptosis resistance of pancreatic cancer cells against TRAIL Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies with an overall life expectancy of ...
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