Conclusions.Taken together, the present study indicates that VNS may attenuate brain damage after TBI by inhibiting oxidative stress, inflammation, and apoptosis, possibly through the NF-kappa B/NLRP3 signaling pathway.Tang, YunliangDong, XiaoyangChen, GengfaYe, WenKang, JunweiTang, YangFeng, Zhen...
et al. Polyhydroxylated Metallofullerenols Stimulate IL-1 beta Secretion of Macrophage through TLRs/MyD88/NF- kappa B Pathway and NLRP3 Inflammasome Activation. Small 10, 2362-2372, doi: 10.1002/smll.201302825 (2014).Chen Z, Liu Y, Sun B, Li H, Dong J, Zhang L, et al. Poly...
NLRP3 gene knockout blocks NF-κB and MAPK signaling pathway in CUMS-induced depression mouse model. Behav. Brain Res. 2017, 322, 1-8. [CrossRef] [PubMed]Su WJ, Zhang Y, Chen Y, et al. NLRP3 gene knockout blocks NF-kappaB and MAPK signaling pathway in CUMS-induced depression mouse...
Beyaert, Karin and colleagues discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-[kappa]B pathway and the NLRP3 inflammasome.doi:10.1038/ni.3772Inna S Afonina...
Sodium Butyrate Inhibits Oxidative Stress and NF-κB/NLRP3 Activation in Dextran Sulfate Sodium Salt-Induced Colitis in Mice with Involvement of the Nrf2 Signaling Pathway and MitophagySodium butyrateUlcerative colitisInflammationOxidative stressNF-kappa B...
NLRP3PyroptosisBackground and aim: The Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-kappa B)/NLRP3 inflammasome signaling pathway is essential in the pathogenesis of hepatic ischemia/ reperfusion (HIR) injury. Pyroptosis is a pminflammatory programmed cell death that is related to ...
Renshen Shouwu extract enhances neurogenesis and angiogenesis via inhibition of TLR4/NF-kappa B/NLRP3 signaling pathway following ischemic stroke in ratsRenshen shouwu extract (RSSW)Ischemic strokeNeurogenesisAngiogenesisNLPR3Ethnopharmacological relevance: Renshen Shouwu extract (RSSW) is a patented ...
We evaluated the effects of aerobic exercise on inflammation and insulin signaling pathway in the prefrontal cortex of diabetic rats. Male SD rats were fed with a normal diet or a high-fat diet (HFD) for 8 weeks. Then, part of the HFD rats was selected for aerobic exercise training. Our...
H2S, along with CO and NO, has been recognized as the third physiological gas signaling molecule that plays an active role in fighting various lung infections. However, the mechanism by which GYY4137 affects cecal ligation and puncture (CLP)-induced acute lung injury (ALI) is not understood. ...
HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production. J Hepatol 2017;66(4):693-702.X. Yu, P. Lan, X. Hou et al., "HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing ...