NAFLDInflammatory responseBackground: Non-alcoholic fatty liver disease (NAFLD) has a high incidence and mortality rate, and a rapid course of clinical development. Although miR-125b is closely associated with the pathogenesis of liver fibrosis and hepatocellular carcinoma, the role of miR-125b in...
Nonalcoholic fatty liver disease (NAFLD) is characterized by high levels of nonesterified fatty acids (NEFA), inflammation, and hepatic steatosis. Inflammation plays a crucial role in the development of fatty liver. Resveratrol (RSV) supplement could improve inflammatory response and hepatic steatosis,...
Results A total of 381 lncRNAs were found to be not only highly expressed in NAFLD, but also is going to go even higher in NASH. A novel LncRNA-gm9795 was significantly highly expressed in liver tissues of NASH animal models and NASH cell models. By staining with Nile red, we found ...
Consumption of Cy-3-G is associated with lower risks of non-alcoholic fatty liver disease (NAFLD), liver fibrosis, obesity, atherosclerosis, and inflammation. However, whether Cy-3-G has effects on inflammasome formation and activation thereby protects against alcohol-induced liver damage remain ...
NAFLD Non-alcoholic fatty liver disease NAS Non-alcoholic fatty liver disease activity score NASH Non-alcoholic steatohepatitis NF-κB Nuclear factor-κB ROS Reactive oxygen species TGF Transforming growth factor TNF Tumor necrosis factor Wt Wild-type References Chalasani, N.; Younossi, Z.; Lavine...
NAFLD has a high prevalence in Western countries and it is an important cause of CLD [2]. In CLD, cirrhosis is a terminal stage of damage, where the compensated state progresses to a decompensated disease. Liver fibrogenesis is a dynamic, highly integrated molecular and cellular process, ...
phloretamide;diabetes;NAFLD;Nrf2;NF-κB;rats 1. Introduction Type-1 diabetes mellitus (DM) is the most common endocrine disorder that results from a deficiency of insulin, mainly due to autoimmune destruction of the pancreatic beta-cells [1]. The disease is associated with several co-morbidities...
The development of non-alcoholic fatty liver disease (NAFLD) is associated with obesity and disorders of lipid metabolism in patients with metabolic syndrome. With a global increase in recent years of the obese population, the number of cases of NAFLD has also increased [1,2]. A global meta-...