Smith, L. (1994), Reflections on the next stage of the epidemiological transition. In: C.D. Mathers, J. McCallum and J.M. Robine (eds.) Advances in health expectancies. Canberra: Australian Institute of Health and Welfare, AGPS, pp. 53-57.Smith, L.R. (1994) `Reflections on the ...
Puberty marks a transition to adolescence and a life phase during which girls and boys acquire resources that are essential for becoming parents of the next generation. It also marks the beginning of reproductive life with a transition to functional gamete production. The preconceptional phase (that...
Breast cancer, the world’s most commonly diagnosed cancer, is a heterogeneous disease that demands appropriate diagnosis for better patient management. Thus, the understanding of the molecular mechanisms of tumor heterogeneity, as well as the characteri
In this context, New Approach Methodologies (NAMs), namely in vitro and in silico methods to reduce animal testing and enhance assessment accuracy, are gaining prominence in the transition to next generation RA (NGRA) [56], and in the context of Safe and Sustainable by Design (SSbD) approach...
After 30 years of consensus-derived diagnostic categories in mental health, it is time to head in new directions. Those categories placed great emphasis on enhanced reliability and the capacity to identify them via standardized checklists. Although this
Jessup, M.et al. Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure.Circulation124, 304–313 (2011). ...
In a study by Uno et al., liver transcriptomic data were scrutinized to assess phase I cytochromes P450, flavin-containing monooxygenases, and carboxylesterases, along with phase II UDP-glucuronosyltransferases, sulfotransferases, and glutathione S-transferases [45]. Comparative analysis across a ...
Additional challenges loom for the next phase in building a future-proof and durable immune repertoire to protect against oncoming viral variants. Table 1. Review of next-generation coronavirus vaccines in development. 2. New Situation Caused by SARS-CoV-2 Evolution SARS-CoV-2 has been ...
D (subsequent encounter).Subsequent encounter refers to an encounter after the patient has received active treatment, during the recovery phase. S (sequela).Sequela refers to a complication or condition that is a direct result of an injury, such as a scar. ...
[23,52,53,54]. True cellular dormancy, on the other hand, occurs when disseminated cells (i.e., cells that have reached a metastatic site) are arrested in the G0 phase of the cell cycle and resistant to host defenses and therapy. Thus, an interplay between reversible quiescence and ...