depressionintegrated treatmentspersonalizationpharmacological interventionspsychosocial interventionsrecovery21ST-CENTURY PARADIGM SHIFTSMENTAL-HEALTH-CARECOGNITIVE REMEDIATIONPSYCHIATRIC-DIAGNOSISPurpose of reviewMajor depressive disorder (MDD) is a common and burdensome severe mental disorder, which is expected to ...
Patients with treatment-resistant depression who do not respond adequately to several consecutive treatments for major depressive disorder are increasingly asking about deep brain stimulation (DBS) as an option, following a number of media reports of its efficacy. But is it really a promising treatment...
Major depression is a severe psychiatric syndrome with very high prevalence and socioeconomic impact. Its pathophysiology is poorly known, yet several neurotransmitter systems and brain areas have been implicated. Selective serotonin (5-hydroxytryptamine [5(-HT)]) reuptake inhibitors (SSRIs) and seroton...
JAMA Insights Women's Health November 27, 2023 Postpartum Depression—New Screening Recommendations and Treatments Tiffany A. Moore Simas, MD, MPH, MEd1,2; Anna Whelan, MD1,2; Nancy Byatt, DO, MS, MBA1,2 Author Affiliations JAMA. 2023;330(23):2295-2296. doi:10.1001/jama.20...
Treatments affecting gastrointestinal motility and sensitivity, as well as gut barrier function, are promising; medical foods have also been tested in small trials in IBS, with a good safety profile and some efficacy. Personalized treatment strategies for patients with FBDs, based on various diagnostic...
We classify the degree of innovation as first-in-indication, i.e., drugs for the treatment of a condition for which no approved medical treatments existed; first-in-class, i.e., drugs with a molecular mechanism of action that had not been used by previously approved medical treatments; and...
Depression treatments currently offered or on the horizon include corticotropin-releasing hormone antagonists; dexamethasone; partial adrenalectomy; long-termcognitive behavioral therapy; ketamine and other NMDA antagonists; benzodiazepines; anesthetics;deep brain stimulation;transcranial magnetic stimulation; exogenou...
Due to the growing gap between the demand and supply of therapeutic services for people suffering from depression, with this study, we are investigating the effectiveness and factors of influence of new approaches in group treatments for depression. Two previous studies have already identified boulderin...
What tools can clinicians use to help women make treatment decisions for depression during pregnancy, while breast-feeding, and during perimenopause and menopause? Women constitute two thirds of patients suffering from common depressive disorders, making the treatment of depression in women a substantial...
Fresh insights into changes in the brain linked to depression could pave the way for new therapies. The study also sheds light on why a certain category ofantidepressant drugsstop working in some people. Researchers at the University of Edinburgh pinpointed a key molecule that may protect the ...