Speaking to Inpharma , Professor Lance Blumhardt from Queen's Medical Centre, Nottingham, UK, who was one of the lead investigators in the trial, said that the he believes that the drug offers certain advantages over currently available treatments....
There is currently no cure for Multiple Sclerosis. Existing treatments aim to help patients manage symptoms. What are new MS drugs in development? There are currently several MS experimental treatments under clinical trials currently. For a complete list, visit the https://mstrust.org.uk/about-ms...
Solabegron relaxes the bladder smooth muscle by stimulating beta-3 adrenoceptors, a novel mechanism compared to older established drug treatments for overactive bladder syndrome such as the anticholinergic agents. Astellas Pharma have developed the first commercially available β3 adrenergic receptor, ...
Influenza has a long history of causing morbidity and mortality in the human population through routine seasonal spread and global pandemics. The high mutation rate of the RNA genome of the influenza virus, combined with assortment of its multiple genomi
Conclusions: Generalised pairwise comparisons make it possible to assess the benefit–risk balance of new treatments using a single statistical test for any number of prioritised outcomes. The benefit–risk assessment was not in favour of adding erlotinib to gemcitabine for the treatment of patients ...
We classify the degree of innovation as first-in-indication, i.e., drugs for the treatment of a condition for which no approved medical treatments existed; first-in-class, i.e., drugs with a molecular mechanism of action that had not been used by previously approved medical treatments; and...
With no available cure MS is the focus of intense study for the hundreds of scientists across the world who are working on new treatments for this disabling disease. MS is more common in temperate climates. With around 100,000 people suffering from MS in the UK the country has one of the...
We study ENLIGHT as a PO tool, aimed at prioritizing treatments for patients, based on measuring bulk tumor transcription (Fig. 16A). We also developed a deep-learning framework that predicts genome-wide tumor gene expression from H&E slides and created ENLIGHT-DP [36] by applying ...
Cardiovascular diseases (CVDs) remain a major health concern worldwide, where mesenchymal stem cells (MSCs) therapy gives great promise in their management
Some treatments may also be associated with a bell-shaped dose-response curve, where increasing dose leads to increasing efficacy only up to a point, whereupon further dose increases lead to decreasing efficacy [30]; in this scenario, high doses of treatment may be responsible for pseudo-...