Features the immune system-regulating molecule interferon beta-1b indicated for treatment of relapsing-remitting multiple sclerosis in ambulatory patients. Reduction of the frequency and severity of the exacerbations; Clinical trials; Action; Pharmacokinetics; Dosage and administration; Adverse effects; ...
The discovery of medications with clinically meaningful antidepressant and antipsychotic effects in the mid-twentieth century was a landmark in the treatment of mental disorders. However, soon afterwards it was recognised that in some patients, their condition showed limited or no response to these dru...
The effects on Hsp90 client-proteins were also analyzed after treatment with 17-AAG (2 µM) for 24 h. Numbers below each panel are densitometric ratio of each band to respective actin levels. The shown blots are representative of three different experiments with similar results. Full ...
Avik Ray, MD, MS; Julie M. Paik, MD, ScD, MPH; Deborah J. Wexler, MD, MSc; et al. Abstract Full Text JAMA Intern Med. Published online February 10, 2025. doi:10.1001/jamainternmed.2024.7811 This comparative effectiveness research study examines the outcomes of treatment with sodium-...
can only be meaningful based on input from experts within a specific therapeutic area who can judge on the added clinical value of a treatment. They fall into the responsibility of Health Technology Assessment bodies such as the National Institute for Health and Care Excellence in the UK. ...
2021 Comparison of New Pharmacologic Agents With Triptans for Treatment of MigraineA Systematic Review and Meta-analysis Chun-Pai Yang, MD, PhD1,2; Chih-Sung Liang, MD3; Ching-Mao Chang, MD, PhD4,5,6; et al Cheng-Chia Yang, PhD7; Po-Hsuan Shih, MD6,8; Yun-Chain Yau, MS9; Kuo...
Drug resistance represents a significant obstacle in cancer treatment, underscoring the need for the discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), a subclass of deubiquitinating enzymes, play a pivotal role in protein deubi
(Figs2–4), revise the diagnosis of the taxon, as well as elucidate its phylogenetic position based on this revision. In addition, the lifestyle of the species is re-assessed. Furthermore, the treatment of characters for phylogenetic analyses, which are potentially influenced by a convergent ...
(BLENREP®, GlaxoSmithKline) is a first-in-class anti-BCMA ADC that was granted accelerated approval by the FDA in August 2020 as a monotherapy treatment for adult patients with RRMM who had received at least four prior therapies; belantamab mafodotin includes an anti-CD38 mAb, the ...
Ms Cohen rejects the “tough guy insults”, saying the mayor had been the first to call for closures, but “with each announcement, the city faced resistance from the state”. Mr Cuomo ultimately announced on March 20 that he would put New York “on pause” 48 hours later, choosing his...