As a result, he expects this to shift the treatment of lower-risk MDS-associated anemia. “I think that these results of the COMMANDS trial suggest that this will be the standard-of-care for now for our patients,” Garcia-Manero, lead study author and professor in the Department of ...
The heterogeneity of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) has led to a multiplicity of treatments, from cytotoxic agents to signal transduction modulators, cell cycle inhibitors, and epigenetic therapies. While some have shown promising initial results, the outlook for AML ...
Current standard treatments for myelodysplastic syndromes (MDS) are limited by less than optimal success rates because of genetic and clinical variability of the disease. Emerging research is currently focused on improving response rates, delaying transformation to acute myeloid leukemia (AML), and improv...
Dr Eckfeldt on the Treatment Paradigm and Current Challenges in MDS Treatment Trends: JAK Inhibitor Selection in Myelofibrosis Dissecting the Current Treatment Landscape in MDS Dr Sekeres on Luspatercept Plus Lenalidomide in Non–5q Deletion MDS ...
for 2/3 line cervical cancer, submissions for first-line advanced gastric and cervical cancer treatments are under regulatory review. Ongoing Phase III trials reveal substantial benefits for diverse PD-L1 expressing patients, offering new options to address critical unmet need in this patient ...
The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSF) are two of the most complex and sophisticated concierges that defend the cen
Treatments targeting the dopaminergic system alleviate PD symptoms but are not able to slow the neurodegenerative process that underlies PD progression. The nucleus striatum comprises a complex network of projecting neurons and interneurons that integrates different neural signals to modulate the activity of...
Additionally, there are preliminary data that MDSCs may affect the sex dimorphism and differences between genders in the survival rates and response to treatments in various conditions, as they may present different levels in male versus female subjects [23]. The research in the field is ...
International Parkinson and movement disorder society evidence-based medicine review: Update on treatments for the motor symptoms of Parkinson’s disease. Mov. Disord. 2018, 33, 1248–1266. [Google Scholar] [CrossRef] Bjørklund, G.; Dadar, M.; Anderson, G.; Chirumbolo, S.; Maes, M. ...
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