MDS NCCN指南根据环状铁粒幼细胞(RS)百分比和血清EPO水平对无del(5q)异常且有症状性贫血的低风险MDS患者进行分类,但未指定红细胞输血负担。 对于有症状性贫血的RS- 低风险MDS患者,建议在血清EPO ≤500 mU/mL的患者中,将Rytelo作为红细胞生成刺激剂(ESA)或罗特西普(Luspatercept)之后的1类二线治疗,在血清EPO >...
对75岁以上的高龄、高危MDS进行亚组分析显示[2],阿扎胞苷组患者OS及2年生存率均显著高于传统治疗组;同时,阿扎胞苷治疗可减少患者输血依赖,且不良反应发生率和程度更低。一项韩国的回顾性分析中,年龄>65岁的MDS患者接受阿扎胞苷治疗的OS显著优于另一HMA地西他滨,根据IPSS预后分层,高危患者接受阿扎胞苷治疗OS略有优势...
Nannya等[6]研究发现,在MDS中TP53突变和阿扎胞苷疗效正相关。因此,对于伴TP53突变的MDS患者,适合去甲基化药物治疗。 本例患者因“反复皮下瘀斑5年,加重伴牙龈出血1个月”就诊,血象提示三系减少,骨髓象增生活跃,粒红两系可见病态造血,原粒+原幼单占8%,按照MDS诊断标准明确诊断为MDS-EB-1,按IPSS-R预后积分系统...
Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome. DNA Repair 2003, 142, 1-13.Casorelli, I.; Offman, J.; Mele, L.; Pagano, L.; Sica, S.; D'Errico, M.; Giannini, G.; Leone, G.; Bignami, M.; Karran, P. Drug treatment in...
如果获得批准,TIBSOVO将成为第一个也是唯一一个获得批准的针对易感IDH1突变的MDS患者的靶向治疗药物。 参考来源:Servier announces FDA filing acceptance and Priority Review forTibsovo® (ivosidenib tablets) in the treatment of IDH1-mutated relapsed or refractory (R/R) myelodysplastic syndromes (MDS). Servi...
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic stem cell disorders. Although the currently used classification schemes and prognostic algorithms, which are based predominantly on morphologic assessment of blood and marrow smears, have been shown to be valid for defining disease...
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Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In most cases, multiple drugs are used, as resistance to single agents occurs almost universally. For this reason, elucidation of mechanisms that confer simultaneous resistance to different drugs with different targe...
38.3–50.3). Sensitivity analyses consistently produced similar estimates. A slight improvement in treatment outcomes was observed after 2013. Furthermore, 25 studies reported outcomes for 3564 individuals with pre-extensively drug-resistant tuberculosis, of which 63.3% achieved successful treatment (95%CI...
Nintedanib is a tyrosine kinase inhibitor that was approved for the treatment of patients with idiopathic pulmonary fibrosis in 2014. The most common side effect of Nintedanib is diarrhea, and thrombocytopenia is a rare side effect of Nintedanib. The exa