Ubara Y. New therapeutic option for autosomal dominant poly- cystic kidney disease patients with enlarged kidney and liver. Ther Apher Dial 2006;10(4):333--41.Ubara,Y.New therapeutic option for autosomal dominant polycystic kidney disease patients with enlarged kidney and liver. Therapeutic ...
New research from Yale School of Medicine has discovered that the gene Glis2 is a component of PKD signaling and may also be a new target for the treatment of the disease. The paper, "Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease...
Over 600,000 people in the U.S., and 12 million worldwide, are affected by the inherited kidney disease known as autosomal-dominant polycystic kidney disease, or ADPKD. The disease is characterized by the proliferation ofcyststhat eventually debilitate the kidneys, causing kidney failure in half ...
In the course of studying the genetics of chlorambucil mutagenesis, we have uncovered a new model for autosomal polycystic kidney disease (PKD). In the homozygous condition, the gene, jcpk, causes a very severe disease characterized by cysts in all segments of the nephron. Death usually occurs...
Radadiya PS et al (2021)Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic Kidney Disease. JCI Insight, 6(8) Imai T et al (2021) Deferasirox, a trivalent iron chelator, ameliorates neuronal damage in hemorrhagic Stroke models. Naunyn Schmiedebergs Arch Pharmacol 394(...
Major advances in the treatment of ANCA associated-renal vasculitides, IGA nephropathy and renal autosomal dominant polycystic disease were published within the past year. There is neither clear benefit of early initiation of renal replacement therapy in the intensive care unit nor with the use of ch...
by Westmead Institute for Medical Research Kidney affected by cysts. Credit: Dr Gopi Rangan A cheap, safe and effective treatment to polycystic kidney disease may soon be available, thanks to a new national clinical out of Westmead, Australia, which is trialing water to treat the disease. ...
Infant, NewbornKidney Diseases [chemically inducedRandomized Controlled Trials as TopicSepsis [drug therapyThis is the protocol for a review and there is no... Bethan Richards,Samuel Whittle,R Buchbinder - John Wiley & Sons 被引量: 49发表: 2011年 Human placental glutathione S-transferase activity...
A conversation with his brother, Sorin Fedeles, who studiespolycystic kidney disease, led the pair to theorize that these compounds might also be good candidates for treating kidney cysts. At the time, research in ADPKD was beginning to suggest that kidney cyst cells also experience oxidative stres...
Targeting AMP-activated protein kinase (AMPK) for treatment of autosomal dominant polycystic kidney disease. Cell Signal. 73, 109704 (2020). Article CAS PubMed Google Scholar Banskota, S. et al. Salicylates ameliorate intestinal inflammation by activating macrophage AMPK. Inflamm. Bowel Dis. 27,...