The article presents information on developments in the treatment of melanoma. It is considered as the most important cause of death from dermatological diseases. New molecules have been approved in 2011 for the treatment of advanced melanoma. One is Ipilimumab, which is the first agent ever ...
The panelists agreed that chemotherapy and transplantation will be mainstays of treatment for now, but they believe that the addition of targeted therapies would improve outcomes. “I think the survival curves are going up, not just because of supportive care, but because in fact we understand th...
Resistance to therapy inhibits the effectiveness of current treatments for aggressive cancers such asmalignant melanoma. The onset of resistance relates to the capability of tumor cells to circumvent the stress induced by the treatment. In order to survive, cancer cells develop a series of adaptive m...
Melanoma cells are notorious for their high plasticity and ability to switch back and forth between various melanoma cell states, enabling the adaptation to sub-optimal conditions and therapeutics. This phenotypic plasticity, which has gained more attention in cancer research, is proposed as a new pa...
Recently, advances in the treatment of melanoma that activate the immune system by targeting the molecules CTLA4 and PD1, and targeting kinases such as BRAF, have shown promise. Although these drugs have led to improved patient survival, they do not cure melanoma. Therefore, additional therapies ...
Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J. Med. Chem. 54, 1473–1480 (2011). Article CAS ...
CONSERVE 2021 Guidelines for Reporting Trials Modified for the COVID-19 Pandemic Creation and Adoption of Large Language Models in Medicine Global Burden of Cancer, 2010-2019 Global Burden of Long COVID Global Burden of Melanoma Global Burden of Skin Diseases, 1990-2017 Global Disparities in Parkin...
L. et al. Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma. J. Clin. Invest. 115, 1903–1912 (2005). CAS PubMed PubMed Central Google Scholar Kaufman, H. L. et al. Local delivery of vaccinia virus expressing multiple ...
Metastatic melanoma is an aggressive form of cancer characterised by poor prognosis and a complex etiology. Until 2010, the treatment options for metastatic melanoma were very limited. Largely ineffective dacarbazine, temozolamide or fotemustine were the only agents in use for 35 years. In recent ...
SYDNEY, Aug. 17 (Xinhua) -- Australian scientists said they have found a way to help dermatologists better determine a patient’s risk of developing melanoma, pointing to improved understanding and treatment of the major skin cancer. The team from the University of Queensland uncovered the specif...