In this review we will summarize the results obtained by the use of nanoparticles and extracellular vesicles in glioblastoma. A great interest is raising from these studiesthat underlined the efficacy and specificity of this treatment for glioma, reducing side-effects associated with conventional ...
In cell lines with the wild- type promoter, 20–35% of cells died following etoposide treatment, but in those homozgous for SNP309, only 2–3% of cells died. This low death rate was found to be due to poor induction of the p53 transcriptional programme. But does this affect the risk...
The conventional chemotherapeutic treatment against glioblastoma involves administering the drug temozolomide, at a high cost and with little guarantee of effectiveness. Adverse effects of the dose needed to cross theblood-brain barrier, which protects thecentral nervous system, include damage to bone marr...
" he said. "There is no question that there are patients who are being cured with glioblastoma. For many of my colleagues around the country might disagree with me, they of course would be wrong, because its true. It's a small, incremental population every year, but there are people who...
Glioblastoma Multiforme (GBM) is a highly aggressive brain tumor for which there is no treatment. Oncolytic Viruses (OVs) are attenuated tumor-selective viruses designed to replicate in and kill tumor cells without affecting normal tissue. Herpes Simplex Virus type-1 derived oncolytic vectors (oHSV...
Nanoparticle-Delivered Antisense MicroRNA-21 Enhances the Effects of Temozolomide on Glioblastoma Cells Glioblastoma (GBM) generally exhibits high IC50 values for its standard drug treatment, temozolomide (TMZ). MicroRNA-21 (miR-21) is an oncomiR overexpresse... JS Ananta,R Paulmurugan,TF Massoud ...
New therapeutic strategies regarding endovascular treatment of glioblastoma, the role of the blood–brain barrier and new ways to bypass it The treatment protocols for glioblastoma multiforme (GBM) involve a combination of surgery, radiotherapy and adjuvant chemotherapy.Despite this multimodal ... S,Pes...
Although the biological studies of individual gene play a vital role in clinical treatment, the emergent functions and behaviors of individual genes in the context of the whole biological systems still require further investigation9,10. As the biological function is usually completed by the cooperation...
Glioblastoma multiforme (GBM) is an extremely aggressive malignant brain tumor. Despite advances in treatment modalities, it remains largely incurable. This unfavorable prognosis for GBM is at least partly due to the lack of a successful drug delivery system across the blood-brain barrier (BBB). Th...
Temozolomide ['Temodal'; Schering-Plough] was recently approved in Europe and has subsequently been launched in the UK for the treatment of patients with glioblastoma multiforme showing progression or recurrence after standard therapy. * It has also been unanimously recommended for accelerated approval ...