The two-step process also appeared to help with cell memory. In CAR T-cell therapy, boosting these memory properties helps T cells better recognize and combat cancer over time. In recent studies using T cells grown with the lab's new approach, 63% of patients experienced a partial or compl...
There have been major advances in the immunotherapy of cancer in recent years, including the development of T cell engagers — antibodies engineered to redirect T cells to recognize and kill cancer cells — for the treatment of haematological malignancies. However, the field still faces several chal...
Recently, numerous immune treatment methods, such as immune checkpoint blockade of co-inhibitory receptors using anti-PD1/PDL1 and anti-CTLA4, dendritic cell vaccines, and cytokine therapy, have been designed and therapeutically used to address tumor cell immune evasion [17]. Among these methods, I...
CAR-T cell therapy has revolutionized the field of cancer treatment, particularly in the management of hematological malignancies. However, its application in solid tumors has presented unique challenges due to the complexities of the tumor microenvironment, such as heterogeneity and the hostile tumor mi...
www.nature.com/scientificreports OPEN received: 30 November 2014 accepted: 27 November 2015 Published: 06 January 2016 Discovering new mTOR inhibitors for cancer treatment through virtual screening methods and in vitro assays Ling Wang1,2,*, Lei Chen1,*, Miao Yu1, Li-Hui Xu4, Bao...
T cell-mediated adaptive immune response is controlled by both positive costimulation and negative coinhibition, generated mainly by the interaction between the B7 family and their receptor CD28 family. Coinhibition is exploited by prostate cancer as an immune evasion pathway. Overexpression of coinhibit...
Researchers at the University of Cincinnati (UC) College of Medicine have discovered that cell metabolism plays an important role in the ability of cells to start a survival program called autophagy, an unwanted side effect of some anti-cancer drugs that helps some tumor cells dodge treatment and...
24 in Nature reveal the structure of this molecule, opening new paths for cancer treatment development. The ALK molecule is a receptor — a protein that sits in the membrane of a cell and responds to other molecules that bind to it — found primarily in the brain and centra...
Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy. Chin J Cancer. 2015;34:541–53. Article CAS PubMed Google Scholar Baglio SR, Rooijers K, Koppers-Lalic D, Verweij FJ, Pérez Lanzón M, Zini N, et al. Human bone marrow- and adipose...
Since more comprehensive and profound insights about intratumoral microbiota are continuously emerging, new methods for the early diagnosis and prognostic assessment of cancer patients have been under examination. In addition, interventions based on intratumoural microbiota show great potential to open a ...