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Sewell. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell, 2023: 186(16), P3333-3349.E27. DOI: doi.org/10.1016/j.cell. 多快好省,购物逛京东!m.jd.com/#sksLeft=0&st=0&fls08007=undefined...
Dr. Ho: Well, that's a really good question. We do not know exactly how CAR-T cell treatment in liver cancer is related to the particular etiology of what you discussed in liver cancer. Obviously, tumors with different etiologi...
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[1]Li, CH,et al.Long-term outcomes of GD2-directed CAR-T cell therapy in patients with neuroblastoma.Nat Med(2025). https://www.nature.com/articles/s41591-025-03513-0 [2]Chen T,et al.Current challenges and th...
1.Engineered TCR-T CellI mmunotherapy in Anticancer Precision Medicine: Pros and Cons. Front Immunol. 2021;12: 658753. 2. Evolution of CD8+ T Cell Receptor(TCR) Engineered Therapies for the Treatment of Cancer. Cells. 2021 Sep;10(9): 2379....
为解决 CAR-T 细胞疗法中抗原相关耐药及 “脱靶” 毒性问题,研究人员开展了抗原依赖耐药机制及替代抗原研究。他们揭示了多种耐药机制,发现多个潜在替代抗原。这为优化 CAR-T 细胞疗法、攻克癌症治疗难题提供了新思路,值得科研读者一读。 在癌症治疗的漫长征程中,免疫疗法可谓是一颗耀眼的新星,而 CAR-T 细胞疗法(嵌合...
Mohanty R, Chowdhury C R, Arega S, et al. CAR T cell therapy: a new era for cancer treatment[J]. Oncology Reports, 2019, 42(6): 2183-2195. Singh A K, McGuirk J P. CAR T cells: Continuation in a revolution of immunotherapy[J]. The Lancet Oncology, 2020, 21(3): e168-e178...