Many studies have shown that microRNAs (miRNAs) play important roles in the development of idiopathic pulmonary fibrosis (IPF). The purpose of this review is to systematically summarize the recent advance of miRNAs in the pathology of IPF, highlighting the new research progress and their ...
"With the current pandemic and the observation that pulmonary fibrosis occurred in many patients in Asia years after recovering from Severe Acute Respiratory Syndrome (SARS), our new research findings may have far-reaching implications," says Esteban Gabazza, IGB affiliate, professor at Mie University...
In addi- tion, the progress of a clinical trial of pirfenidone, the first randomized placebo- controlled study on the drug treatment of IPF in Japan, is described. Various treatment strategies for IPF suggested by basic research are also introduced. 展开 关键词: Idiopathic pulmonary fibrosis ...
A NEW SYNDROME OF HYPERURICEMIA, PULMONARY FIBROSIS, AND RENAL DISEASE IN A KINDREDPediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending from molecular biology to epidemiology. Use of model ...
Moreover, pirfenidone, a commercially and clinically available drug approved for treating idiopathic pulmonary fibrosis (IPF), effectively suppressed silica-... Xiang Li a,Xiaopei Yan b,Yanli Wang a,... - 《Experimental Cell Research》 被引量: 8发表: 2018年 \\{NICE\\} guidance on pirfenidone...
This review discusses how molecular switches and macromolecular complexes regulate CFTR and speculates about some promising areas for additional study in this dynamic and rapidly moving area of research. Abstract Cystic fibrosis transmembrane conductance regulator (CFTR), a Cl−-selective ion channel, ...
68 This chronic inflammation ultimately leads to pulmonary fibrosis, often progressing to pneumoconiosis and lung cancer. The damaging inflammation responsible for driving these processes is dependent on aberrant activation of the NLRP3 inflammasome.25, 69, 70 In response to silica and asbestos, ...
therapy for cardiac disease. Kaminski, whose group pioneered research in microRNA in lung fibrosis, saw the potential for use of miR-29 in pulmonary fibrosis, as did Eva van Rooij, the scientist who discovered the role for miR-29 in cardiac fibrosis and is a senior co-author on the paper...
Idiopathic pulmonary fibrosis (IPF) is the most common and most deadly type of interstitial lung disease. It is fatal and progressive, characterized by scarring and damage of lung tissue next to the alveoli. This process causes an irreversible loss of the tissue’s ability to exchange oxygen, ...
8. Idiopathic pulmonary fibrosis: diagnostics and treatment. 9. Problems of occupational pathology. 10. Inborn defects and inherited lung diseases. 11. Burning issues of thoracic surgery. Preliminary Programme: Day 1 09:30-10:00 Infections and critical patients: emerging problems and clinical strategi...