idiopathic pulmonary fibrosisalveolar epithelial cellsepithelial-mesenchymal transitionlong noncoding RNAsMany studies have shown that microRNAs (miRNAs) plChenggui MiaoYouyi XiongGuoxue ZhangJun ChangExperimental Lung ResearchPandit KV, Milosevic J, Kaminski N. 2011. MicroRNAs ...
A NEW SYNDROME OF HYPERURICEMIA, PULMONARY FIBROSIS, AND RENAL DISEASE IN A KINDREDPediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending from molecular biology to epidemiology. Use of model ...
The target audience for these research grants will be U.S.-based investigators interested in research that is relevant to pulmonary fibrosis. The focus of the research grants will be programs that have a high likelih...
Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis 2022, Frontiers in Pharmacology Vascular Smooth Muscle Cells Mechanosensitive Regulators and Vascular Remodeling 2022, Journal of Vascular Research New insights into profibrotic myofibroblast formation in systemic sclerosis: When...
et al. Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: role of transmembrane SCF and the PAR-2/PKC-alpha/Raf-1/p44/42 signaling pathway. Am. J. Pathol. 182, 2094–2108 (2013). Article CAS Google Scholar Varricchi, G., Raap, U., Rivellese, F., Marone,...
68 This chronic inflammation ultimately leads to pulmonary fibrosis, often progressing to pneumoconiosis and lung cancer. The damaging inflammation responsible for driving these processes is dependent on aberrant activation of the NLRP3 inflammasome.25, 69, 70 In response to silica and asbestos, ...
Idiopathic pulmonary fibrosis (IPF) is the most common and most deadly type of interstitial lung disease. It is fatal and progressive, characterized by scarring and damage of lung tissue next to the alveoli. This process causes an irreversible loss of the tissue’s ability to exchange oxygen, ...
C. et al. Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis. Sci. Adv. 6, eaba1972 (2020). Article CAS Google Scholar Fiore, V. F. et al. αvβ3 Integrin drives fibroblast contraction and strain stiffening of soft ...
This review discusses how molecular switches and macromolecular complexes regulate CFTR and speculates about some promising areas for additional study in this dynamic and rapidly moving area of research. Abstract Cystic fibrosis transmembrane conductance regulator (CFTR), a Cl−-selective ion channel, ...
HSCs in the bone marrow that produce blood cells, and research has found that mitochondria may be involved in this process. The fusion protein MfN1 (mitofusin 1/2) and fission protein FIS1 (mitochondrial fission protein 1) play a key role in erythropoiesis. Overexpression of FIS1 leads to ...