The main pathological characteristics of pulmonary fibrosis (PF) include damage to alveolar epithelial cells, fibroblast activation and extracellular matrix accumulation, which gradually lead to damage to the lung structure and decreased lung function. It is important to understand the cellular and ...
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The use of two mouse models of pulmonary fibrosis helped the identification of the transcription factor RUNX2 as a regulator of the transition of alveolar fibroblasts to pathological fibroblasts. Yinshan Fang Sanny S. W. Chung Jianwen Que
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Transcription factors govern various functions in the cell such as proliferation, repair, regenerative programs, etc. Currently, there are no available dru
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Genes correspond to regions within DNA, a molecule composed of a chain of four different types of nucleotides—the sequence of these nucleotides is the genetic information organisms inherit. DNA naturally occurs in a double stranded form, with nucleotides on each strand complementary to each other....
Acute lung injury elicits a profibrotic wound healing program in monocyte-derived macrophages. Their abundance is associated with pulmonary fibrosis in individuals recovering from COVID-19 pneumonia. Leif Erik Sander News & Views04 Oct 2024Nature Immunology ...