Building on the individual clinical case reports, our latest research showed that when Trikafta is taken during pregnancy, it does cross the placenta in animal models, accumulating in key cystic fibrosis tissues including the pancreas, liver, lungs and the brain. This is a significant finding, fir...
Cystic fibrosis (CF) is an autosomal recessive inherited disorder that affects -80,000 individuals worldwide. Mutations in the CF transmembrane conductance regulator gene (CFTR) cause dysfunction of the CFTR protein, a cAMP- and PKA-activated chloride channel. Decades of research and development ...
Cystic fibrosis (CF) is a genetic disease affecting multiple organs, in which, primarily the lungs and digestive system, become obstructed by mucus, causing difficulties in breathing and digesting food. Researchers have now found that people suffering from CF have limited ability to uptake and use ...
Cystic fibrosis transmembrane conductance regulator (CFTR), a Cl−-ion channel, assembles into dynamic macromolecular complexes. Understanding how these complexes regulate the intracellular trafficking and activity of CFTR provides a unique insight int
The latest research shows that miRNAs exert crucial effects on gene regulation and may play a prominent role in cell physiology. Improved understanding of the sequence of events has already allowed the use of miRNAs for diagnostic and prognostic purposes and, more specifically, for detecting susceptib...
- 《Erj Open Research》 被引量: 0发表: 2024年 13 Cases of false negative cystic fibrosis newborn screening in Greece Within the last year, all 50 states in the United States have adopted newborn screening (NBS) protocols for cystic fibrosis (CF), the most common fatal aut... M Noni,...
Newborn screening (NBS) for pre-symptomatic detection of CF currently relies on a two-stage immunoreactive trypsinogen (IRT) and cystic fibrosis ... DiBattista, Alicia,McIntosh, Nathan,M Lamoureux,... - 《Journal of Proteome Research》 被引量: 0发表: 2018年 加载更多来源...
Newborn Screeing for Cystic Fibrosis and Its Impact on the Clinical Diagnostic LaboratoryLo, Stanley
(Lechtenberg et al.2014; Yang et al.2019b). However, it may be possible that they could modulate inflammatory responses, especially the neuroinflammation. There is preliminary evidence of several NLRs family members role in the adaptive immune system. However, extensive research is needed to ...
New research could provide roadmap for more effective drug discovery for cystic fibrosis byMcGill University A recent study led by Gergely Lukacs, a professor at McGill University's Faculty of Medicine, Department of Physiology, and published in the January issue ofCell, has shown that restoring ...