with the exception of teriparatide, which is reserved for women and men with the most severe osteoporosis, all of these newer drugs are first-line therapy for osteoporosis in postmenopausal women. However, only bisphosphonates are also currently approved for this indication in men and in patients ...
WNT7B, that stimulates new bone growth (shown in pink on the right). The protein could become a target for new drugs to treat osteoporosis and other conditions related to bone loss. Credit: Washington University
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being of the host. Recent studies have demonstrated that the GM may significantly influence bone metabolism and degenerative skeletal diseases, such as osteoporosis (OP). Interventions targeting GM modification, i...
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being of the host. Recent studies have demonstrated that the GM may significantly influence bone metabolism and degenerative skeletal diseases, such as osteoporosis (OP). Interventions targeting GM modification, i...
This is to say the least, big news for everyone who’s long been waiting for a drug that would speed the path to market of drugs that treat multiple age related illnesses. When this happens, aging will no longer be so dreary. We can all then look forward to longer, healthier lives. ...
43 Small population-wide shifts in blood glycaemia (of the magnitude seen in our analyses) can have a large relative effect on the proportion of a population exceeding a diagnostic threshold level near the tail of the distribution (figure 4), as evidenced by other drugs that produce small ...
Ankylosing spondylitis (AS) is a common rheumatic disorder distinguished by chronic inflammation and heterotopic ossification at local entheses sites. Currently available medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modif
The overall structure of the potential drugs, including atoms arrangements, can be elucidated by MSn experiments. High-Resolution Mass Spectrometry (HRMS) is a well-established and widely accepted analytical technique for novel drugs characterization, due to higher resolving power and higher mass ...
In particular, due to the side effects of existing drugs, the market for osteoclasts’ formations’ regulators is scarce; it is urgent to screen safe and effective leading compounds applied in therapy for osteoporosis [9,10]. The search for structurally novel compounds regulating osteoclastogenesis ...
Exosomes from Adipose Tissues Derived Mesenchymal Stem Cells Overexpressing MicroRNA-146a Alleviate Diabetic Osteoporosis in Rats. Cell. Mol. Bioeng. 2021, 15, 87–97. [Google Scholar] [CrossRef] Ko, J.H.; Oh, J.Y. The Effect of miR-146a on the Gene Expression of Immunoregulatory ...