Mikhail Gishizky, Ph.D., spokesman for SUGEN, explained that his company is looking for site-specific drugs to disrupt the sequence of events that takes place when normal cells become cancerous. Gishi...
Dr. Mathew Garnett, co-lead author from the Wellcome Sanger Institute and Open Targets, said: "The Cancer Dependency Map is a huge effort to identify all the weaknesses that exist in different cancers so we can use this information to empower the next generation of precision cancer treatments....
The best-studied PARPs generate PAR modifications and include PARP1 and the tankyrase PARP5A, both of which are targets for cancer therapy with inhibitors in either clinical trials or preclinical development. There are 15 additional PARPs, most of which modify proteins with MAR, and their biology...
Proof-of-concept studies in cell-culture and animal models have validated STAT3 and STAT5 proteins as promising molecular targets for novel cancer therapies, including small-molecule inhibitors of STAT signalling. Abstract Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, ...
New targets for cancer therapydoi:10.1016/0098-2997(93)90001-TR.C. CoombesMolecular Aspects of Medicine
Pancreatic cancer remains one of the deadliest malignancies worldwide. Since five-year survival rate for pancreatic ductal adenocarcinoma (PDAC) is only about 3% in patients, PDAC is very difficult to treat with surgery worldwide. To develop novel treatm
Recent advances in next generation sequencing (NRG) have provided compelling evidence that endometrial cancers result from heterogeneous somatic mutations. These findings argue that a catalog of molecular aberrations that cause endometrial cancer is critical for the proper classification of these tumors and...
Drug Resistance and Novel Targets for Cancer Therapy: An Overview of Recent Findings This document provides an overview of recent research on drug resistance and novel targets for cancer therapy. It emphasizes the challenges posed by the co... Ouverney, Gabriel,Hottz, Déborah,Robbs, Bruno Kaufmann...
Cancer Chemotherapy and Pharmacology(2008) Advertisement Nature Reviews Molecular Cell Biology (Nat Rev Mol Cell Biol)ISSN1471-0080(online)ISSN1471-0072(print) Sign up for theNature Briefingnewsletter — what matters in science, free to your inbox daily. ...
Gordon J. Freeman, PhD:Professor of Medicine at Dana-Farber Cancer Institute and Harvard Medical School Virna Cortez-Retamozo, PhD:Group Head, Distinguished Scientist, Onco-Pharmacology, SANOFI-US Yuelei Shen, PhD:Founder, President & CEO, Biocytogen ...