Cancer is known as the leading cause of human mortality. Several risk factors are associated with developing cancer like genetic factors, immune status, microbiome, diet, and habits. Probiotics, a group of beneficial microbes and related products, have drawn significant attention in prevention and tr...
Targeting the inside of cells with biologicals: chemicals as a delivery strategy. BioDrugs. 2021;35(6):643–71. Article CAS PubMed PubMed Central Google Scholar Pan BT, et al. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes...
the intratumoralF. nucleatumandMethylobacteriummay decrease the density of tumor-infiltrated T cells and promote T cell dysfunction in tumor tissues to induce tumor progression. (4) Immunosuppression: Lastly, intratumoralN. ramosa,S. aureus, HBV and HCV can...
Studying salivary miRNAs has become increasingly attractive for oral squamous cell cancer (OSCC) (Table2). The potential of miRNAs in saliva for non-invasive cancer diagnosis, especially for OSCC, has drawn interest in recent years (Fig.1). The strategy takes advantage of the fact that miRNAs ...
and TAMs. They used this lentiviral strategy to engineer the expression of IFNα in Kupffer cells and TAMs. This strategy results in macrophage activation, T-cell activation, reshaping of the TME, and antitumor activity. The reported lentiviral vector-based strategy may pave the way for the deve...
1C) with the ultimate goal, “if” successful, to induce an exponential amplification of endogenous anti-cancer mechanisms (Fig. 1D). This strategy stands on the premise that the targeted benign cells are (1) present in the TME and (2) differ from their counterpart in the rest of a ...
Targeting other cullin complexes, such as ZBTB, holds therapeutic potential. Regulating the ubiquitination levels of Atg14L through GPCR ligands can potentially be a pharmacological strategy to activate autophagy in the central nervous system. This approach may help inhibit neural dysfunction caused by ...
Search strategy and study selection To access all studies presenting the effects of metals on the prevention or occurrence of cancer in humans, a systematic search without historical restrictions was conducted until May 31, 2024 in the following databases: Scopus, PubMed, and Web of Science for ...
and TAMs. They used this lentiviral strategy to engineer the expression of IFNα in Kupffer cells and TAMs. This strategy results in macrophage activation, T-cell activation, reshaping of the TME, and antitumor activity. The reported lentiviral vector-based strategy may pave the way for the deve...
Scheiblich S, Kaluza K, Gorr IH, Walz A, Abiraj K, Cassier PA, Sica A, Gomez-Roca C, de Visser KE, Italiano A, Le Tourneau C, Delord JP, Levitsky H, Blay JY, Rüttinger D (2014) Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therap...