the intratumoralF. nucleatumandMethylobacteriummay decrease the density of tumor-infiltrated T cells and promote T cell dysfunction in tumor tissues to induce tumor progression. (4) Immunosuppression: Lastly, intratumoralN. ramosa,S. aureus, HBV and HCV can...
Immunotherapy has been developed as an innovative strategy for cancer treatment, using the body's immune system to recognize and eliminate cancer cells. Despite its considerable potential, immunotherapy is frequently impeded by the immunosuppressive attributes of the TME [73]. TME can establish a prot...
Re-educating macrophages has been pursued via a variety of approaches [12]. Kerzel et al. [102] developed an original strategy to target Kupffer cells and TAMs in liver metastasis. They took advantage of lentiviral vectors, which are preferentially taken up by liver mononuclear phagocytes, and ...
Beclin1, known as a multifunctional protein, exerts significant crosstalk roles between autophagy and cancer. PTM of Beclin1 regulate autophagy and have been found to be associated with promoting chemotherapy resistance in cancer [42]. Most E3 ligases have a vital role in inhibiting autophagy through...
This indicates that FTO’s activity contributes to breast cancer progression, and targeting FTO could represent a novel therapeutic strategy [66]. Qu et al. demonstrated through in vivo and in vitro experiments that senescent neutrophils enhance the expression of FTO in breast cancer cells by ...
Towards Healthcare is a leading global provider of technological solutions, clinical research services, and advanced analytics to the healthcare sector, committed to forming creative connections that result in actionable insights and creative ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an exceptionally contagious single-stranded RNA virus with a strong positive contagion. The COVID-19 pandemic refers to the swift worldwide dissemination of SARS-CoV-2 infection, which began
Scheiblich S, Kaluza K, Gorr IH, Walz A, Abiraj K, Cassier PA, Sica A, Gomez-Roca C, de Visser KE, Italiano A, Le Tourneau C, Delord JP, Levitsky H, Blay JY, Rüttinger D (2014) Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therap...
WGCNA (weighted gene co-expression network analysis) is a powerful genetic analysis strategy that relies on a systematic bioinformatics algorithm. This method is used to identify highly and coordinately expressed genes within modules to determine the patterns of genetic association between different ...
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