Based on World Health ...mization epidemiological data, Sartorius1 has esti...d that on any one daydoi:10.3928/0048-5713-19811101-06Frank J AydSLACK IncorporatedPsychiatric Annals
Credit: Pixabay/CC0 Public Domain A team of researchers working at Nanjing Medical University in China, has developed a new antidepressant drug that elicits an antidepressant effect in mice in just two hours. In their paper published in the journalScience, the group describes their novel approach ...
Escitalopram, a selective-serotonin reuptake inhibitor, is a commonly used antidepressant. It ameliorates cognitive impairment and could selectively attenuate phosphorylated tau accumulation in stressed rats by regulating hypothalamic–pituitary–adrenal axis activity and the insulin receptor substrate/glycogen syn...
Targeting these pathways has the potential to yield antidepressant effects, e.g. using cytokine antagonists, minocycline, Cox-2 inhibitors, statins, acetylsalicylic acid, ketamine, ω3 poly-unsaturated fatty acids, antioxidants, and neurotrophic factors. These six pathways offer new, pathophysiologically...
Although drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and efficacy. Because many drug–target combinations exist, it would be useful to explore possible interactions computationally. Her
The mood-elevating properties of ketamine were unanticipated and subsequently led to ketamine’s use as an antidepressant in MDD/TRD and now in multiple other psychiatric disorders. This initial serendipitous finding has been exploited to come up with various ketamine-like drugs and in fact the S-...
They are also very important from a therapeutic perspective, as they are used as drugs (for example, anticonvulsant–ethosuximide) or tested as drug candidates. These derivatives show antifungal, antibacterial, antidepressant, or analgesic activities. Several reports describe the antitumor activity of ...
Antidepressant drugs are effective in the acute treatment of depression. Antidepressant medications are often the first treatment option prescribed by health professionals.Antidepressant medications can make psychotherapy more effective for some people. The largest effects relative to placebo are seen in ...
The Emperor's New Drugs:A€ Exploding the Antidepressant Myth. London:A€The Bodley Head.Kirsch I (2011) The Emperor's New Drugs: Exploding the Antidepressant Myth. New York, New York, Basic Books.Kirsch, I. The emperor's new drugs: exploding the antide- pressant myth. New York: Basic...
After the triptans, a calcitonin gene-related peptide blocker (telcagepant) is the first acute medicine that has been developed primarily for treatment of acute migraine. Otherwise, the new drugs have been developed first for other purposes, like anticon