DrugsregistrationBedinvetmabEnflicoxibEsafoxolanerEtamsylateFrunevetmabMirtazapineTetryzolineTigilanol tiglateIn 2021, 8 novel pharmaceutical agents for small animals were released on the German market: The specific monoclonal antibodies bedinvetmab (Librela (R)) and frunevetmab (Solensia (R)), ...
The Antidepressant Drugs Market accounted for $13.75 billion in 2016 and is estimated to reach $15.98 billion by 2027, registering a CAGR of 2% from 2021 to 2027.Antidepressants are a class of drugs that work against chemical imbalances of neurotransmitters in the brain, reducing the symptoms of...
Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet medical need worldwide. The pathogenesis of AD involves various pathophysiological events, including the accumulation of amyloid and tau, neuro-inflammation, and ne
Escitalopram, a selective-serotonin reuptake inhibitor, is a commonly used antidepressant. It ameliorates cognitive impairment and could selectively attenuate phosphorylated tau accumulation in stressed rats by regulating hypothalamic–pituitary–adrenal axis activity and the insulin receptor substrate/glycogen syn...
The mood-elevating properties of ketamine were unanticipated and subsequently led to ketamine’s use as an antidepressant in MDD/TRD and now in multiple other psychiatric disorders. This initial serendipitous finding has been exploited to come up with various ketamine-like drugs and in fact the S-...
their clinical use. Non-invasive approaches like intranasal administration, P-glycoprotein (P-gp) inhibition, pro-drugs, and carrier/targeted nanocarrier-aided delivery systems (alone or often in combination) hold positive clinical prospects for brain targeting if explored further in the right direction...
New drugs for FBDs target key pathophysiological mechanisms and differ from current therapies by improving the abnormal bowel habit as well as other symptoms, such as abdominal pain and bloating. Gut luminal factors, such as food, microbiota and bile acids, and their interaction with each other an...
Safety and Tolerability of Antidepressants Problems abound when assessing the comparative acceptability and safety of antidepressant drugs. The findings of double-blind randomised placebo- and compa... C Manson,R Gordon,D Baldwin - Springer International Publishing 被引量: 0发表: 2016年 ...
Structures of FDA approved VEGFR-2 inhibitor drugs featuring bi-aryl moiety. Full size image In continuation to our work in discovering new anticancer agents in general and VEGFR-2 inhibitors in particular16,17,18,19,20,21it deemed of interest to explore new chemotypes for their VEGFR-2 inhibi...
Review of allopregnanolone agonist therapy for the treatment of depressive disorders. Drug Des Devel Ther. 2021;15:3017–26. Article PubMed PubMed Central Google Scholar Sartim AG, Guimarães FS, Joca SRL. Antidepressant-like effect of cannabidiol injection into the ventral medial prefrontal ...