We recruited patients from 20 hospitals (Australia, Canada and Germany) during the period from 2009 to 2016 (Fig.1). The eligibility criteria, included (1) age greater than 18 years and (2) World Health Organization definition of influenza-like illness (fever of 38 °C or higher, cough ...
Neutrophils are implicated in multiple homeostatic and pathological processes, but whether functional diversity requires discrete neutrophil subsets is not known. Here, we apply single-cell RNA sequencing to neutrophils from normal and inflamed mouse tissues. Whereas conventional clustering yields multiple alt...
Alterations in haematological variables reported in this study were found to be within the normal physiological range for calves of this age, and thus no negative effects on animal welfare were determined using these measures. Furthermore, the difference in rectal body temperature between supplemented ...
are unable to form NETs [224]. In vivo demonstrations of such structures have been provided by a limited number of human infectious and non-infectious diseases, as well as several animal infection models [222,223]. It is not clear whether NETs alter the normal course of the inflammatory...
Neutrophils and macrophages were treated with saline (PBS, 0 nM TSP-1) or TSP-1 (1, 10 or 100 nM). Results are expressed as fold change over the PBS (0 nM TSP-1) control group. Boxes show median (centre line) and interquartile range (edges), whiskers show the range of val...