In summary, the secretion of BAFF from neutrophils promotes B cell survival and proliferation, plasma cell differentiation and antibody production. In chronic diseases such as COPD, SLE or RA, these effects are enhanced, exacerbating the disease through an autoreactive B cell response and autoantibody...
In transcellular migration, transmigratory cups high in ICAM-1 and VCAM-1 capture crawling neutrophils that then make their way through the cells. Once out in tissues, a burst of transcriptional activity in part mediated by local G-CSF production initiates generation of cytokines by neutrophils. ...
Many of neutrophils are recruited in draining popliteal LNs after OVA is injected into the footpad of OVA/CFA immunized mice by means of lymphatic vessels, which provides new evidence about the roles of neutrophils in adaptive immunity in vivo [42]. However, following induction of sterile ...
Download: Download high-res image (1MB) Download: Download full-size image Figure 2. Macrophage-derived Tnfa is necessary for β cell loss in zMIR fish (A) Intra-islet macrophage number in zMIR fish from 64–72 h based on 30 s/frame time-lapse videos hourly. Data represent means ± SEM...
Rheumatic diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), are a group of auto-inflammatory disorders associated with substantial morbidity and mortality. One unifying feature of these diseases ...
OVA/CFA immunized mice by means of lymphatic vessels, which provides new evidence about the roles of neutrophils in adaptive immunity in vivo [42]. However, following induction of sterile inflammation by photodynamic therapy (PDT), neutrophils migrates to dLNs mainly through crossing high endothelial...
In particular, secondary necrotic cells release considerably less ATP, although they release activated caspase-3 and proteolytically processed autoantigens.4–6 As fast-acting effector cells of the innate immune system, neutrophils are rapidly recruited to sites of infection, where they exert their ...
Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiat
63 Where noted, MAGIC [v2.0.3]64 was used to impute the data, based on an automatically calculated level of diffusion (parameter t=auto). Imputed data was solely used for the purposes of visualization. Differential gene expression analysis...
Points represent the means and bars the S.D. of triplicate determinations. Table 2. Effects of Scavengers of Active Oxygen Species on 'Ethylene Generation by PMA-Stimulated HL-60 Cells and Neutrophils HL-60 (pmole Agent ethylene/30 min/5 Neutrophils x lo6cells) (% Control) None Mannitol (...