(CNS) disease, including CNS multiple myeloma, plasma cell leukemia, allogeneic stem cell transplant within 6 months before apheresis or ongoing treatment with immunosuppressants, creatinine clearance <40 mL/min, absolute lymphocyte concentration <300/μL, absolute neutrophil count <750 cells/mm3, ...
Neutrophil activation and clonal CAR-T re-expansion underpinning cytokine release syndrome during ciltacabtagene autoleucel therapy in multiple myeloma Shuangshuang Yang, Jie Xu, Yuting Dai, Shiwei Jin, Yan Sun, Jianfeng Li, Chenglin Liu, Xiaolin Ma, Zhu Chen, Lijuan Chen, Jian...
Neutrophil engraftment is defined as 3 consecutive measurements of absolute neutrophil count (ANC) ≥ 500 cells/μL on 3 different days after CASGEVY infusion, without use of the unmodified rescue CD34+cells. In Trial 2, the median (min, max) time to neutrophil engraftment was 29 (12, 56)...
Neutrophil Engraftment Failure There is a potential risk of neutrophil engraftment failure after treatment with LYFGENIA. Neutrophil engraftment failure is defined as failure to achieve three consecutive absolute neutrophil counts (ANC) ≥ 0.5 × 109 cells/L obtained on different days...
Monocyte (pink), lymphocyte (green), neutrophil (cyan), eosinophil (red). c Hemolysis ratio of the blood after incubation with MS@D-HMP (n = 3 biologically independent samples, mean ± SD. Unpaired, two-tailed student’s t-test). d Quantitative evaluation of adhered platelets on...
He was treated for neutropenic sepsis in view of low absolute neutrophil count and recent history of chemotherapy. During his admission, he developed abdominal distension, high bilious aspirates, and diarrhea with bloody stools. Abdominal X-ray showed dilated bowel loops. Impression was septic ileus...
It is known that a graft content of more than 5 million CD34+ cells/kg body weight is safe, resulting in fast recovery of absolute neutrophil count and platelets before days 14 and 21, respectively, in a major fraction of patients and, most important, only has a minor risk for ...
Monitor absolute neutrophil counts (ANC) and manage infections according to standard guidelines and medical judgement. In the event of neutrophil engraftment failure, patients should be infused with rescue CD34+cells.Delayed Platelet EngraftmentDelayed platelet engraftment has been observed with exagamg...
Neutrophil engraftment failure was defined as failure to achieve 3 consecutive absolute neutrophil counts (ANC) ≥ 0.5 × 109 cells/L obtained on different days by Day 43 after infusion of Skysona. Monitor neutrophil counts until engraftment has been achieved. If neutrophil engraftment...
(ULN); serum alanine transaminase <2 × ULN; serum direct bilirubin ≤2.0 mg/dL (except for patients with isolated elevation of indirect bilirubin relating to a confirmed diagnosis of Gilbert syndrome); total white blood cell count >3000/μL; absolute neutrophil count >1500/μL; ...