Programmed death ligand 1 (PD-L1) has been shown to be inducibly expressed on neutrophils to suppress host immunity during polymicrobial sepsis, virus and parasite infections. However, the role of PD-L1 on neutrophil-mediated antifungal immunity remains wholly unknown. Here, we show that the ...
inducing regulatory T cells in pregnancy or suppress T cell activation (Arg-1, PD-L1 or CCL17 mediated). By secretion of BAFF or APRIL, neutrophils can promote B cell activation, survival, and differentiation. B-cell helper neutrophils in spleen are invol...
Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma. J. Exp. Clin. Cancer Res. 34, 141 (2015). PubMed PubMed Central Google Scholar Xu, W. et al. Immune-checkpoint protein VISTA regulates antitumor immunity by ...
i PD-L1 is upregulated in sepsis patients’ neutrophils and activates PI3K/Akt signaling to delay septic neutrophil death. j–m Hypoxia regulates HIF family proteins to delay neutrophil apoptosis. (By Figdraw: PPRSAd2e22). ROS reactive oxygen species, Bim Bcl-2-interacting mediator of cell ...
neutrophil PD-L1 expression both in vitro and in vivo. In addition, PKM2 nuclear translocation was increased after LPS stimulation, which promoted PD-L1 expression by directly interacting with and activating signal transducer and activator of transcription 1 (STAT1). Inhibition of PKM2 activity or ...
Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway. Gut. 2017;66:1900–11. Uribe-Querol E, Rosales C. Neutrophils in Cancer: two sides of the same coin. J Immunol Res. 2015;2015:983698. Article PubMed PubMed Central...
Neutrophil elastase (human), (purified) 中性白细胞弹性蛋白酶(人), (纯化) 品牌:Enzo CAS No.: 储存条件:-20℃ 纯度:95+% 产品编号 (生产商编号) 等级规格运输包装零售价(RMB)库存情况参考值 BML-SE284-0100 –100 µg–5,670.00–– * 干冰运输、大包装及大批量的产品需酌情添加运输费用 ...
The prognostic impact of tumoral programmed death-ligand 1 (PD-L1) expression in correlation with neutrophil-to-lymphocyte ratio (NLR) was retrospectively assessed in 83 patients with completely resected stage I squamous cell carcinoma of the lung, as PD-L1 is a potent regulator of cancer ...
The depletion of neutrophils enhances the stemness of CD8+ T cells to inhibit tumor metastasis in aged male mice, potentially by regulating the PD-1/PD-L1 axis and Treg cells, while offering no advantages and could even cause adverse effects in young mice. Procyanidin C1 reversed the tumor-...
The left barplot shows the decreased PD-L1 expression of neutrophils in anti-Ly6G group (n = 8). n, IHC of CD68 in tumour regions of mice treated with isotype control or anti-Ly6G antibody (n = 6). o, FACS analysis showing the expression of surface and intracellular Ly6G in ...