Programmed death ligand 1 (PD-L1) is not only an important molecule in mediating tumor immune escape, but also regulates inflammation development. Here we showed that PD-L1 was upregulated on neutrophils in lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS...
inducing regulatory T cells in pregnancy or suppress T cell activation (Arg-1, PD-L1 or CCL17 mediated). By secretion of BAFF or APRIL, neutrophils can promote B cell activation, survival, and differentiation. B-cell helper neutrophils in spleen are invol...
Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma. J. Exp. Clin. Cancer Res. 34, 141 (2015). PubMed PubMed Central Google Scholar Xu, W. et al. Immune-checkpoint protein VISTA regulates antitumor immunity by ...
inducing regulatory T cells in pregnancy or suppress T cell activation (Arg-1, PD-L1 or CCL17 mediated). By secretion of BAFF or APRIL, neutrophils can promote B cell activation, survival, and differentiation. B-cell helper neutrophils in spleen are invol...
The prognostic impact of tumoral programmed death-ligand 1 (PD-L1) expression in correlation with neutrophil-to-lymphocyte ratio (NLR) was retrospectively assessed in 83 patients with completely resected stage I squamous cell carcinoma of the lung, as PD-L1 is a potent regulator of cancer ...
neutrophil PD-L1 expression both in vitro and in vivo. In addition, PKM2 nuclear translocation was increased after LPS stimulation, which promoted PD-L1 expression by directly interacting with and activating signal transducer and activator of transcription 1 (STAT1). Inhibition of PKM2 activity or ...
HMGB1 PD-L1 PD-1 Neutrophil Immunosuppression Apoptosis 1. Introduction Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The pathogenesis of sepsis is complex, including inflammatory imbalance, immune dysfunction, mitochondrial damage, coagulation dysfunction...
During breast cancer development, programmed cell death 1 ligand 1 (PD-L1) overexpression in neutrophils leads to delayed apoptosis and promotes neutrophil hyperproliferation in the lung to form a premetastatic niche, which is beneficial for pulmonary metastasis. Platycodin D (PlaD), a triterpenoid ...
(DGKG) in tumor endothelial cells, which then activates the ZEB2/TGF-β1 axis, promoting angiogenesis and immune suppression in HCC. Targeting DGKG can enhance the efficacy of dual blockade of PD-1 and VEGFR-2 therapies [154].Therefore, besides direct tumor-killing strategies, attempting to ...
Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway. Gut. 2017;66:1900–11. Uribe-Querol E, Rosales C. Neutrophils in Cancer: two sides of the same coin. J Immunol Res. 2015;2015:983698. Article PubMed PubMed Central...