Programmed death ligand 1 (PD-L1) is not only an important molecule in mediating tumor immune escape, but also regulates inflammation development. Here we showed that PD-L1 was upregulated on neutrophils in lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS...
Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma. J. Exp. Clin. Cancer Res. 34, 141 (2015). PubMed PubMed Central Google Scholar Xu, W. et al. Immune-checkpoint protein VISTA regulates antitumor immunity by ...
inducing regulatory T cells in pregnancy or suppress T cell activation (Arg-1, PD-L1 or CCL17 mediated). By secretion of BAFF or APRIL, neutrophils can promote B cell activation, survival, and differentiation. B-cell helper neutrophils in spleen are invol...
inhibiting angiogenesis has become an important strategy for cancer treatment [151,152,153,154]. Evidence suggests that hypoxia induces the overexpression of diacylglycerol kinase γ (DGKG) in tumor endothelial cells, which then activates the ZEB2/TGF-β1 axis, promoting angiogenesis and immune suppre...
The prognostic impact of tumoral programmed death-ligand 1 (PD-L1) expression in correlation with neutrophil-to-lymphocyte ratio (NLR) was retrospectively assessed in 83 patients with completely resected stage I squamous cell carcinoma of the lung, as PD-L1 is a potent regulator of cancer ...
HMGB1 PD-L1 PD-1 Neutrophil Immunosuppression Apoptosis 1. Introduction Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The pathogenesis of sepsis is complex, including inflammatory imbalance, immune dysfunction, mitochondrial damage, coagulation dysfunction...
During breast cancer development, programmed cell death 1 ligand 1 (PD-L1) overexpression in neutrophils leads to delayed apoptosis and promotes neutrophil hyperproliferation in the lung to form a premetastatic niche, which is beneficial for pulmonary metastasis. Platycodin D (PlaD), a triterpenoid ...
However, neutrophils can migrate to lymph nodes mediated by CCR7 or CXCR4 where they interact with T cells, either assuming an antigen presenting role via MHCII or MHCI, inducing regulatory T cells in pregnancy or suppress T cell activation (Arg-1, PD-...
[19, 20] reported that neutrophils from HIV-1-infected individuals suppress T cell function through the production of programmed death ligand 1 (PD-L1) and ROS, suggesting that HIV-1 infection induces immunosuppressive activity via neutrophils with an inhibitory effect on T cell function. However,...
Multiple experiments have confirmed that CMTM6, as a cancer cell protein, exhibits a regulatory relationship with the surface expression of PD-L1 cells in both murine and human bone marrow cells [26]. CMTM6 has been observed to co-localize with PD-L1 in the plasma membrane and recirculating ...