Programmed death ligand 1 (PD-L1) is not only an important molecule in mediating tumor immune escape, but also regulates inflammation development. Here we showed that PD-L1 was upregulated on neutrophils in lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS...
Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma. J. Exp. Clin. Cancer Res. 34, 141 (2015). PubMed PubMed Central Google Scholar Xu, W. et al. Immune-checkpoint protein VISTA regulates antitumor immunity by ...
However, neutrophils can migrate to lymph nodes mediated by CCR7 or CXCR4 where they interact with T cells, either assuming an antigen presenting role via MHCII or MHCI, inducing regulatory T cells in pregnancy or suppress T cell activation (Arg-1, PD-...
inducing regulatory T cells in pregnancy or suppress T cell activation (Arg-1, PD-L1 or CCL17 mediated). By secretion of BAFF or APRIL, neutrophils can promote B cell activation, survival, and differentiation. B-cell helper neutrophils in spleen are invol...
The prognostic impact of tumoral programmed death-ligand 1 (PD-L1) expression in correlation with neutrophil-to-lymphocyte ratio (NLR) was retrospectively assessed in 83 patients with completely resected stage I squamous cell carcinoma of the lung, as PD-L1 is a potent regulator of cancer ...
HMGB1 PD-L1 PD-1 Neutrophil Immunosuppression Apoptosis 1. Introduction Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The pathogenesis of sepsis is complex, including inflammatory imbalance, immune dysfunction, mitochondrial damage, coagulation dysfunction...
Multiple experiments have confirmed that CMTM6, as a cancer cell protein, exhibits a regulatory relationship with the surface expression of PD-L1 cells in both murine and human bone marrow cells [26]. CMTM6 has been observed to co-localize with PD-L1 in the plasma membrane and recirculating ...
(DGKG) in tumor endothelial cells, which then activates the ZEB2/TGF-β1 axis, promoting angiogenesis and immune suppression in HCC. Targeting DGKG can enhance the efficacy of dual blockade of PD-1 and VEGFR-2 therapies [154].Therefore, besides direct tumor-killing strategies, attempting to ...
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen clearance, immune regulation and dise
During breast cancer development, programmed cell death 1 ligand 1 (PD-L1) overexpression in neutrophils leads to delayed apoptosis and promotes neutrophil hyperproliferation in the lung to form a premetastatic niche, which is beneficial for pulmonary metastasis. Platycodin D (PlaD), a triterpenoid ...