In vitro, NETs contained the immunosuppressive ligand PD-L1 responsible for T cell exhaustion; an effect abrogated by using PD-L1 KO NETs. This exhausted state was directly linked to mitochondrial dysfunction in the T cells. Furthermore, NETs were targeted in vivo by treating mice with DNAse ...
The prognostic impact of tumoral programmed death-ligand 1 (PD-L1) expression in correlation with neutrophil-to-lymphocyte ratio (NLR) was retrospectively assessed in 83 patients with completely resected stage I squamous cell carcinoma of the lung, as PD-L1 is a potent regulator of cancer ...
inhibiting angiogenesis has become an important strategy for cancer treatment [151,152,153,154]. Evidence suggests that hypoxia induces the overexpression of diacylglycerol kinase γ (DGKG) in tumor endothelial cells, which then activates the ZEB2/TGF-β1 axis, promoting angiogenesis and immune suppre...
Neutrophil exhaustion may play a key role during the establishment of pathogenic inflammation and immune suppression through elevated expression of inflammatory adhesion molecules such as ICAM1 and CD11b as well as immune-suppressors such as PD-L1. However, the mechanism of neutrophil exhaustion is ...
(DGKG) in tumor endothelial cells, which then activates the ZEB2/TGF-β1 axis, promoting angiogenesis and immune suppression in HCC. Targeting DGKG can enhance the efficacy of dual blockade of PD-1 and VEGFR-2 therapies [154].Therefore, besides direct tumor-killing strategies, attempting to ...
A combined model of serum neutrophil extracellular traps, CD8+ T cells, and tumor proportion score provides better prediction of PD‐1 inhibitor efficacy in patients with NSCLC 血清中性粒细胞细胞外陷阱、CD8+T细胞和肿瘤比例评分的联合模型可更好地预测非小细胞肺癌患者PD-1抑制剂的疗效...
Compared to programmed cell death ligand 1 (PD-L1), the derived NLR-FIB (NF) score had significantly improved accuracy in predicting efficacy and prognosis. In advanced NSCLC patients with targetable oncogenic driver alterations receiving second- or post-line ICI plus chemotherapy, pre-treatment NLR...
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Neutrophil membrane-engineered Panax ginseng root-derived exosomes loaded miRNA 182-5p targets NOX4/Drp-1/NLRP3 signal pathway to alleviate acute lung inju... Neutrophil membrane-engineered Panax ginseng root-derived exosomes loaded miRNA 182-5p targets NOX4/Drp-1/NLRP3 signal pathway to alleviate...
of 1–2μm and the dots were localized in the area occupied by the decondensed chromatin (Figure 1a). Interestingly, polyamine speckles along with the NET DNA filaments were also detected suggesting that endogenous polyamines get incorporated into the protein fraction of the NET too (Figure 1b...