Killian DM,Hermeling S,Chikhale PJ.Targeting the cere-brovascular large neutral amino acid transporter(LAT1)isoform using a novel disulfide-based brain drug delivery system. Drug Delivery . 2007Killian DM, Hermeling S, Chikhale PJ. Targeting the cerebrovascular large neutral amino acid transporter...
We describe a novel strategy to achieve high affinity recognition for the specific, cerebrovascular large neutral amino acid transporter (LAT1) isoform by covalent coupling of small molecules to the amino acid, L-cysteine (L-Cys). L-Cys (as the carrier) was covalently attached via a disulfide...
The orphan transporter Slc6a18 (XT2) is highly expressed at the luminal membrane of kidney proximal tubules and displays ∼50% identity with Slc6a19 (B0AT1), which is the main neutral amino acid transporter in both kidney and small intestine. As yet, the amino acid transport function of...
Killian et al., " Targeting the Cerebrovascular Large Neutral Amino Acid Transporter (LAT1) Isoform Using a Novel Disulfide-Based Brain Drug Delivery System " Drug Delivery 14:25-31 (2007).D.M. Killian, S. Hermeling, P.J. Chikhale, Targeting the cerebrovascular large neutral amino acid ...