Breese CR and GR Breese (1998) The use of neurotoxins to lesion catecholamine-containing neurons to model clinical disorders: approach for defining adaptive neural mechanisms and role of neurotrophic factors in brain, InHighly Selective Neurotoxins: Basic and Clinical Applications(Kostrzewa RM, Ed.) (...
Administration of cycloheximide does not prevent the toxic effects of NMDA on motoneurons, but dramatically reduces the number of pyknotic Schwann cells and DNA fragmentation profiles in the ventral nerve roots. In ovo administration of various tissue extracts (muscle, brain, and spinal cord) from ...
stress resistance- and autophagy-related genes, and antioxidant defense enzyme activities were highlighted. Altogether,C. elegansrepresent a valuable model in nutritional neuroscience for the identification of promising neuroprotective
whose brains are much like ours, during wakefulness and sleep. During sleep, their ventricles, or fluid-filled spaces in the brain,became larger. This has been observed in humans during studies of patients with neurodegenerative syndromes.
Brain-derived neurotrophic factor Bdnf Rattus norvegicus View: In UniProt - opens in external window In NCBI Gene - opens in external window Glial cell line-derived neurotrophic factor Gdnf Rattus norvegicus View: In UniProt - opens in external window In NCBI Gene - opens in external window...
There is evidence that BoNT isoforms can also inhibit neurotransmission in the brain. In this study, we examined whether locally delivered BoNT/A and BoNT/B can attenuate kindling measures in amygdala-kindled rats. Male rats were implanted with a combination infusion cannula-stimulating electrode ...
Lactate transport by cortical synaptosomes from adult rat brain: characterization of kinetics and inhibitor specificity. Since lactate released by glial cells may be a key substrate for energy in neurons, the kinetics for the uptake of L-[U-14C]lactate by cortical synaptic te... MC Mckenna,JT ...
There is evidence that BoNT isoforms can also inhibit neurotransmission in the brain. In this study, we examined whether locally delivered BoNT/A and BoNT/B can attenuate kindling measures in amygdala-kindled rats. Male rats were implanted with a combination infusion cannula–stimulating electrode ...
Naturally occurring toxins can be exquisitely useful chemical tools in neurobiological research. For instance, using an Indian arrow poison extract (curare), the French physiologist Claude Bernard obtained the initial evidence that cells communicate with
Zambenedetti, P., et al., “Identification of lectin binding sites in the rat brain,” Glycoconj. J. 13:341-346, Chapman & Hall (Jun. 1996). Zhou, L., et al., “Expression and Purification of the Light Chain of Botulinum Neurotoxin A: A Single Mutation Abolishes Its Cleavage of SNA...