The selectivity of the toxin effects occurs from differences in the structure of toxin receptors in vertebrate and insect presynaptic membranes, which specify their binding. The a-LCT is a rather toxic principle with LD of 100 pg/kg for crayfishes. It has no visible activity on insects and ...
Neurotoxins and their pharmacological implications : a Biological Council symposium editor, Peter Jenner Raven Press, c1987 KJ Netter 被引量: 0发表: 1988年 Cyanobacterial toxins and human health This review discusses the nature and effects of cyanobacterial toxins, including hepatotoxins, neurotoxins and...
There are several polypeptide neurotoxins that act on nerve terminals to alter the storage and release of neurotransmitters. Electrophysiological studies have shown that these neurotoxins produce a wide variety of effects on the metabolism of transmitters. For the most part, their molecular mechanisms of...
We’ve heard of women (and men) doing crazy things in the name of beauty, but injecting neurotoxins into their calves so they can fit their legs into boots takes the cake. Yes, it is happening. Calf-grazing and knee-high boots are a winter staple, yet they aren’t always comfortable...
In order to study their effects on restriction endonuclease sites, the plasmid DNA was incubated with the neurotoxins (salsolinol or rotenone), extracted and subjected to restriction enzyme digestion (BamHI, EcoRV, HindIII, SalI). Key findings Exposure of rotenone or salsolinol alone to the ...
While consistent with the escape-and-radiate model, our general understanding of the genetic and molecular bases of plant–herbivore coevolution and their potential role in adaptive radiations5,6 remains limited. Terpenoids are the most chemically and structurally diverse compounds known in plants, ...
Many toxins have been isolated from these vemoms found to have effects on the mammalian nervous system and called neurotoxins. Neurotoxins can be classified into the following types according to their effect site:(1) presynaptic neurotoxins;(2)post synaptic neurotoxins; (3) Antiacetylchlinesterase ...
has been missing. Here we present a 4.0 Å cryoEM structure of the α-LCT monomer and a 4.6 Å cryoEM structure of the δ-LIT dimer revealing the molecular architecture of LaTX neurotoxins as well as the molecular details of their oligomerization mechanism prior to membrane insertion....
In this study, researchers of circadian biology imaged the brains of mice, whose brains are much like ours, during wakefulness and sleep. During sleep, their ventricles, or fluid-filled spaces in the brain,became larger. This has been observed in humans during studies of patients with neurodegen...
Commercially important species of shellfish and finfish are known to occasionally present a serious health risk to consumers due to the presence of accumulated marine toxins. A significant number of these marine toxins exert their effects by interaction with voltage sensitive sodium channels in excitable...