Where persistent adverse effects have resulted from the historical use of quinoline antimalaria drugs, we propose a five-point management strategy that we believe will in most cases cause symptoms to abate rapidly: 1) stop taking the quinoline drug;2) stop alcohol, and stop all other liver-...
Although the pathophysiology of schizophrenia is still unknown, it is known that antipsychotics (dopamine receptor blockers) reduce symptoms of schizophrenia, but that recreational drugs like cocaine and amphetamine increase dopamine in the brain and may induce psychosis. The term neurotoxic is used to...
(neurotoxicants), causing alteration in the normal neurological physiology termed asneurotoxicity. The symptoms may develop right away or take time to manifest following exposure. According to the National Institute of Health (NIH),neurotoxicitycan result from exposure to substances used in chemotherapy...
Irons TD, Kelly PE, Hunter DL, Macphail RC, Padilla S (2013) Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish. Pharmacol Biochem Behav 103(4):792–813 Article CAS Google Scholar Dishaw LV, Hunter DL, Padnos B, Padilla S, Stapleton HM (...
which are currently being identified and utilized for cellular, molecular and genetic assays. The behavioral phenotyping inN. cinereanecessary for predictive neurotoxicology and possible neuro-activedrugs discovery, as well as the mechanism based neurotoxicity studies onsaxitoxin, anatoxin-a,methylmercury,chlo...
Symptoms due to toxicity include respiratory arrest, cardiac depression, vomiting, diarrhea, and salivation. In humans, lethal doses have been reported in the range of 40–80 mg/kg b.w. (Boink et al. 1994; Eichler et al. 1982; Lidbeck et al. 1943; Simpson et al. 1980; Whitford 1996...
These symptoms are insufficiently captured with available scales, which should be updated accordingly. Although sometimes severe, neurotoxicity is almost always reversible. The efficacy of steroids and antiepileptic drugs remain unproven and should be further evaluated in prospective trials....
Symptoms of neurotoxicity includememory and concentration problems; confusion; multiple sclerosis or MS-type symptoms; impaired control of the limbs, bladder, or bowels; headaches or migraines; sleep disorders, including sleep apnea; eye problems that are neurological in origin; balance and hearing prob...
When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity. 展开 DOI: 10.1176/ajp.136.7.963 被引量: 46
The symptoms started 1 day to 10 days after starting clarithromycin (mean: 5 days). A total of 71% of patients were under treatment with concomitant medication, and eight patients were undergoing treatment with psychoactive drugs. Patients had a very good outcome after clarithromycin was ...