Similarly, nerve conduction studies may demonstrate carpal tunnel syndrome in those presenting with greater symptomatology in the hands compared to the feet. Asymmetrical lower limb symptoms or signs may be a feature of (superimposed) lumbar radiculopathy (often accompanied ...
[76], muscle atrophy in long-term DPN occurred early in the feet, progressed steadily up the lower legs and was related to the severity of neuropathy leading to weakness at the ankle. Recently, Almurdhi et al. [77], showed that patients with type 2 diabetes have a significant reduction ...
To characterize the interaction of TRPV4 ARD and RhoA in more detail, we recorded two-dimensional1H,15N nuclear magnetic resonance (NMR) spectra of15N-isotope labeled human GDP-bound RhoA (hereafter referred to as RhoA) (Supplementary Fig.3h). The spectral dispersion of the NMR spectra indicated...
Clinically, CIPN manifests itself as deficits in sensory, motor and/or autonomic functions of a varying intensity [15]. Sensory symptoms usually develop first, involve the feet and hands and commonly present as a typical "glove and stocking" neuropathy with the most distal parts of the limbs ...