GPI-AnchorGlycerophosphodiester phosphodiesterase 2 (GDE2) is a six-transmembrane protein that cleaves glycosylphosphatidylinositol (GPI) anchors to regulate GPI-anchored protein activity at the cell surface. In the developing spinal cord, GDE2 utilizes its enzymatic function to regulate the production ...
The ubiquitously expressed cellular prion protein (PrPC) is a copper-binding glycosylphosphatidylinositol (GPI)-anchored protein with particularly high expression levels in the brain [8]. It is localised in membrane lipid raft microdomains where it interacts with a variety of proteins involved in regul...
Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3′-kinase-dependent machinery. Mol. Biol. Cell 17, 3689–3704 (2006). Article CAS Google Scholar Prevostel, C., Alice, V., Joubert, D. & Parker, P. J....
Non-cell-autonomous function of the GPI-anchored protein undicht during septate junction assembly. Cell Rep. 26, 1641–1653.e4 (2019). CAS PubMed Google Scholar Download references Acknowledgements We are thankful to P. Plelan for sending anti-Innexin2 antibodies, H. Kranenburg for advice ...
We have isolated a chick cDNA coding for GPA receptor (GPAR alpha), a GPI-anchored protein that is 70% identical to hCNTFR alpha. Functional analysis revealed that GPAR alpha mediates several biological effects of both GPA and CNTF. Soluble GPAR alpha supports GPA- and CNTF-dependent survival...
[12]. Posttranslation modifications appear to play an important role in dictating strain-specific disease phenotype. The cellular form of the prion protein, or PrPC, is post-translationally modified with the glycosylphosphatidylinositol (GPI) anchor and one or two sialylated N-linked glycans [13,14...
A glycosylphosphatidylinositol (GPI) anchored glycoprotein with structural homology to the L1 CAM extracellular domain. It has six IgG-like protein domains followed by four fibronectin type III domains. Ankyrin G One of three types of ankyrin adaptor proteins that link integral membrane proteins to th...
A glycosylphosphatidylinositol (GPI) anchored glycoprotein with structural homology to the L1 CAM extracellular domain. It has six IgG-like protein domains followed by four fibronectin type III domains. Ankyrin G One of three types of ankyrin adaptor proteins that link integral membrane proteins to th...
CNTN4s are tethered by a glycosylphosphatidylinositol (GPI)-linker to the pre-synaptic membrane9,10; and have several binding partners such as the amyloid precursor protein (APP), secreted APP ectodomain (APPsα), amyloid-like protein 1 (APLP1), and protein tyrosine phosphatase receptor γ (PT...
One gene with a promoter region binding to the DNA binding domain of DRG11 encodes a novel membrane-associated [glycosyl-phosphatidylinositol (GPI)-anchored] protein that we call DRAGON. DRAGON expression is transcriptionally regulated by DRG11, and it is coexpressed with DRG11 in embryonic DRG ...