IL-1 inhibits while IL-2 stimulates the growth of the androgen-sensitive LNCaP cell line. Neither affects growth of AI PC-3 or DU-145 cell lines. IL-1 promotes the neuroendocrine phenotype and IL-2 promotes the exocrine phenotype in prostate cancer. The influence of the immune mediators IL...
Neuroendocrine prostate cancer (NEPC) is a highly lethal variant of castration-resistant prostate cancer (CRPC) with poor survival rates. Current treatment options for NEPC are limited to highly toxic platinum drugs highlighting the urgent need for new t
The ProstateUchida K, Masumori N, Takahashi A, Itoh N, Kato K, Matusik RJ and Tsukamoto T: Murine androgen-independent neuroendocrine carcinoma promotes metastasis of human prostate cancer cell line lncap. Prostate 66: 536-545, 2006.Uchida K, Masumori N, Takahashi A, Itoh N, Kato K, ...
a Principal component analysis (PCA) of ATAC-seq data of NECs including Merkel cell carcinoma (MCC), neuroendocrine prostate cancer (NEPC), gastrointestinal neuroendocrine carcinoma (GINE), and small-cell lung cancer (SCLC). The plot also includes prostate adenocarcinoma (PDX models and TCGA primar...
NEPC-neuroendocrine prostate cancer 神经内分泌前列腺癌 PCa-prostate cancer 前列腺癌 t-NEPC-treatment-emergent NEPC (t-NEPC) hypoxia-directed therapy 2 数据 PCa Beltran data set ---All BAM files and associated sample information are described in Supplementary Table 11; data are deposited in dbGap ...
In contrast primary small cell prostate cancer is very rare (< 1%). A taEuroNEPC should be clinically suspected in patients who have particularly aggressive mCRPC but a disproportionately low prostate-specific antigen (PSA) level and elevated neuroendocrine tumor markers, such as chromogranin A and...
In the human prostate cancer cell line LNCaP, interleukin (IL)‐6 has been shown to regulate both growth and neuroendocrine (NE) differentiation.. We recently observed that IL‐6 mediated growth arrest in LNCaP by activating STAT 3. Since differentiation and growth arrest are often associated pro...
To characterize the functional role of N-Myc as a driver of prostate cancer, we developed unique N-Myc transgenic mouse lines, MPC organoids, and cell line models. Based on histopathological and molecular data, N-Myc overexpression was associated with an induction of the NEPC histological phenoty...
STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP. Prostate 2000;42:88-98. [PubMed: 10617865]Spiotto MT, Chung TD. (2000). STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cells. Prostate 42: 186-195....
F. Isolation of a human prostate carcinoma cell line (DU 145). Int. J. Cancer 21, 274–281 (1978). CAS PubMed Google Scholar Mertz, K. D. et al. Molecular characterization of TMPRSS2-ERG gene fusion in the NCI-H660 prostate cancer cell line: a new perspective for an old model...