Jolkinolide B induces neuroendocrine differentiation of human prostate LNCaP cancer cell line. Biochem Pharmacol. 2002;63:951-957.Liu W K; Ho J C; Qin GW;.Jolkinolide B induces neuroendo- crine differentiation o
In this study, we explored and characterized the functional role of neurotensin (NTS) in cell line and animal models of CRPC with NED. NTS was acutely induced by androgen deprivation in animal models of prostate cancer (PCa) and activated downstream signaling leading to NED through activation ...
Neuroendocrine prostate cancer (NEPC) is a highly lethal variant of castration-resistant prostate cancer (CRPC) with poor survival rates. Current treatment options for NEPC are limited to highly toxic platinum drugs highlighting the urgent need for new t
Neuroendocrine prostate cancer (NEPC) is a lethal form of prostate malignancy [ [[1], [2], [3]]]. While 1–2% of clinical cases arise de novo, an escalating incidence of treatment-induced NEPC has been observed in patients with castration-resistant prostate cancer (CRPC) via neuroendocrine...
(PDF 13484 kb) Abbreviations AdCa (or Ad): Adenocarcinoma; ARS: AR-signaling (gene signature); CCP: Cell cycle progression (gene signature); CRPC: Castration-resistant prostate cancer; FFPE: Formalin-fixed paraffin-embedded; LCNEC: Large cell neuroendocrine carcinoma; LOOCV: Leave-one-out cross...
Methods: To do so, we employed the RNA-seq data of eight prostate related cell lines from Cancer Cell Line Ency- clopedia (CCLE) for chimeric RNA identification. Multiple filtering criteria were used and the candidate chimeric RNAs were characterized at multiple levels and from various ...
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. NEPC arises de novo only rarely; the disease predominantly develops from adenocarcinoma in response to drug-induced androgen receptor signalling inhibition, although the mechan
BioXcel Therapeutics, Inc. today announced that the U.S. Food and Drug Administration (FDA) has designated as a Fast Track development program the investigation of BXCL701 in combination with a CPI for the treatment of patients...
Neuroendocrine prostate cancer (NEPC) has increasingly become a clinical challenge. The mechanisms by which neuroendocrine (NE) cells arises from prostate adenocarcinoma cells are poorly understood. FOXA1 is a transcription factor of the forkhead family
These results indicate that cancer cells can fuse with bystander neural cells in the tumor microenvironment; and cancer cell fusion is a direct route to tumor cell heterogeneity. Prostate cancer (PCa) has a multifaceted relationship with the nervous system. PCa progression is often accom- panied ...