cell linecultured tumor cellsneuroendocrine tumorprostate cancerxenograftThe prevalence of neuroendocrine prostate cancer (NEPC) arising from adenocarcinoma (AC) upon potent androgen receptor pathway inhibition is increasing. Deeper understanding of NEPC biology and development of novel therapeutic agents are ...
Neuroendocrine prostate cancer (NEPC) is a highly lethal variant of castration-resistant prostate cancer (CRPC) with poor survival rates. Current treatment options for NEPC are limited to highly toxic platinum drugs highlighting the urgent need for new t
Uchida K, Masumori N, Takahashi A, Itoh N, Kato K, Matusik RJ and Tsukamoto T: Murine androgen-independent neuroendocrine carcinoma promotes metastasis of human prostate cancer cell line lncap. Prostate 66: 536-545, 2006.K. Uchida, N. Masumori, A. Takahashi, N. Itoh, K. Kato, R. J...
a Principal component analysis (PCA) of ATAC-seq data of NECs including Merkel cell carcinoma (MCC), neuroendocrine prostate cancer (NEPC), gastrointestinal neuroendocrine carcinoma (GINE), and small-cell lung cancer (SCLC). The plot also includes prostate adenocarcinoma (PDX models and TCGA primar...
18. Studies using prostate tumor cell line transplant models are easier to implement but limited in number and fail to replicate all transition stages observed in patients. To better understand NEPC and develop intervention strategies that curtail lineage plasticity, models that accurately reproduce the...
Analysis of PCa transcriptomic profiles suggests that EZH2 and INSM1 have positive correlation in PCa and function together in NEPCa.Methods: To study the expression of INSM1 and EZH2, we did immunofluorescence (IF), immunohistochemistry (IHC), Western blot and RT-qPCR in prostate cancer cell ...
BACKGROUND In the human prostate cancer cell line LNCaP, interleukin (IL)-6 has been shown to regulate both growth and neuroendocrine (NE) differentiation.. We recently observed that IL-6 mediated growth arrest in LNCaP by activating STAT 3. Since differentiation and growth arrest are often asso...
Methods: To do so, we employed the RNA-seq data of eight prostate related cell lines from Cancer Cell Line Ency- clopedia (CCLE) for chimeric RNA identification. Multiple filtering criteria were used and the candidate chimeric RNAs were characterized at multiple levels and from various ...
NEPC-neuroendocrine prostate cancer 神经内分泌前列腺癌 PCa-prostate cancer 前列腺癌 t-NEPC-treatment-emergent NEPC (t-NEPC) hypoxia-directed therapy 2 数据 PCa Beltran data set ---All BAM files and associated sample information are described in Supplementary Table 11; data are deposited in dbGap ...
neuroendocrinechromogranin Aneuron‐specific enolaseBACKGROUND In the human prostate cancer cell line LNCaP, interleukin (IL)-6 has been shown to regulate ... MT Spiotto,TDK Chung - 《Prostate》 被引量: 621发表: 2000年 Do neuroendocrine cells in human prostate cancer express androgen receptor? Th...