OSMI-1, can significantly inhibited NE differentiated PCa cell proliferation in vitro and tumor growth in vivo. Our findings showed that KIF1A promotes NE differentiation to NEPC by regulating the OGT-mediated O-GlcNAcylation. Targeting O-GlcNAcylation...
prostate canceroctreotideneuroendocrinesomatostatinFDGAfter prolonged androgen deprivation therapy, a subset of castrate-resistant prostate cancer patients will develop neuroendocrine prostate cancer (NEPC) associated with resistance to further hormonal therapy and frequent visceral metastases. Imaging the presence ...
BackgroundNeuroendocrine-differentiated prostate cancer (NEPCa) is refractory to androgen deprivation therapy and shows a poor prognosis. The underlying me... Kanayama, MayukoHayano, ToshiyaKoebis, MichinoriMaeda, TatsuyaTabe, YokoHorie, ShigeoAiba, Atsu - 《Prostate》 被引量: 0发表: 2017年 ...
(NE) cells represent one of such phenotypes.4 NE cells are fully differentiated cells that share structural, functional and metabolic properties with neurons.5 They are a normal component of both the developing and the mature prostate epithelium,4–6 although their origin and functional role is ...
Neuroendocrine (NE) differentiation is frequent inprostate cancerand its incidence increases with higher cancer grade. IHC detected NE differentiation in usual prostate cancer does not alter the management. IHC detected NE does not qualify cancer for aNE tumor(i.e. well-differentiated NE tumor,small...
PCa (prostate cancer) 前列腺癌 molecular signature database (MSigDB) 定义了已知基因集,包括H和C1-C7八个系列(Collection/cluster) image.png ONECUT2 is a potential master transcriptional regulator of poorly differentiated neuroendocrine tumors 数据来源: ...
Neuroendocrine (NE) cells are found in the normal prostate as well as in prostate cancer (PC). Their function in the prostate is unclear but it has been hypothesized that they regulate growth and differentiation of prostatic tissue by secretion of bioactive peptides such as calcitonin, bombesin ...
The PC-310 model system is a potentialandrogen-dependent model for studying the role of NE cells in theprogression of clinical prostate cancer. Androgen deprivation ofNE-differentiated prostate cancer may induce the formation of both NE-and AR-positive dormant tumor residues, capable of actively ...
SOX2 is a central factor in embryonal development and maintenance of pluripotency [104]. In healthy tissue or low-grade adenocarcinoma, AR represses SOX2 and maintains the differentiated state. However, SOX2 expression can be induced by direct binding of BRN2 and E2F, among others, to the SOX2...
suggesting that current hormonal therapy designed to suppress AR functions may predispose prostate cancer to NEPC development. Our results suggest an interesting relationship between a classical neurotransmitter and a GPCR in neuroendocrine-differentiated prostate cancer cells. Activated NGF upregulates CHRM4 ...