Conclusion Longitudinal analyses generally indicate that the Neuro-QoL Cognitive Function measure is sensitive to change over time in individuals with HD. Neuro-QoL Cognitive Function changes reflect self-reported cognitive change at 12 and 24 months and performance-based change at 12 months. This ...
在基线时间、每3个月的治疗期间和结束治疗时进行生活质量(QoL)评估。 结果:2018年5月至2020年3月期间,共有7名患者接受了总共48次CED输注,中位年龄为8岁,范围为5-21岁。其中3名患者经历了剂量限制性毒性。观察到4例3级治疗相关不良事件。大...
监测受试者的听力,肿瘤大小,生活质量(qol)的变化以及不良事件.听力损失被定义为与研究基线相比,单词识别分数(wrs)或纯音平均值在统计学上显着下降;肿瘤生长定义为与基线相比体积增加>20%.共20名nf2-swn受试者(中位年龄23.5岁;范围12.5-62.5岁)目标耳听力损失(中位wrs 70%,范围2%-94%)接受贝伐珠单抗维持治疗....
Purpose: Cognitive functioning impacts health-related quality of life (HRQOL) for individuals with Huntington disease (HD). The Neuro-QoL includes two patient-reported outcome (PRO) measures of cognition-Executive Function (EF) and General Concerns (GC). These measures have not previously been ...
Purpose Cognitive functioning impacts health-related quality of life (HRQOL) for individuals with Huntington disease (HD). The Neuro-QoL includes two patient-reported outcome (PRO) measures of cognition鈥擡xecutive Function (EF) and General Concerns (GC). These measures have not previously been ...
We conducted this study in two which involved a comprehensive literature search, patient and professional input, development of an initial item pool, cognitive interviews, and field testing across major neurological disorders (n=511). Item response theory analyses yielded an 18-item unidimensional bank...
Longitudinal analyses generally indicate that the Neuro-QoL Cognitive Function measure is sensitive to change over time in individuals with HD. Neuro-QoL Cognitive Function changes reflect self-reported cognitive change at 12 and 24 months and performance-based change at 12 months. This measure may ...
In the human brain, cannabinoid receptors are localized in areas of higher cognitive functions (forebrain), control of movement (forebrain, midbrain, and hindbrain), and control of motor and sensory functions of the autonomic nervous system (hindbrain) [168]. Activation of CB1 receptors inhibits ...
Cognitive function tests can be organized into broad categories to test intelligence, memory, language, executive function, visuospatial functioning, and disease-specific impairments. Depending on the targets of the feedback, a battery of general tests that assess multiple neuropsychological functions and ...