Shaping of the neural tube also requires localized regions of apoptosis, the lack of which can lead to NTDs. Finally, the neural tube closes with the fusion of the neural folds, forming the dorsal midline of the neural tube. The neural folds give rise to the neural crest, a population of...
Women of childbearing age may present with a history of low socioeconomic status, lack of folic acid supplementation during pregnancy, family history, weakness, fatigue, dyspnea due to anemia, diabetes, and drug intake for epilepsy. Diagnosis is usually made both prenatal and postnatal. Prenatal di...
For instance, CNS-specific type 1 T helper (Th1) cells secrete interferon gamma (IFNγ) following ischemic stroke to recruit immune cells into the CNS [119] and activate cytotoxic CD8+ T cells, which exacerbate CNS damage by inducing apoptosis via caspase activation and Fas ligand signaling [...
NSC abscission usually succeeds, but also fails in ~ 25% of divisions, producing binucleate stem cells and neurons [29•]. Overall, the Cep55 knockout mouse has a small brain due primarily to increased NSC apoptosis, but also premature neurogenesis [29•]. Interestingly, the apoptosis is ...
Evaluation of the mean changes of hippocampal volumes shows that the hippocampus is about 4%–5% smaller in patients with MDD than in healthy con- trols[42]. Using in situ DNA end-labeling demonstrated slightly increased rate of apoptosis in the dentate gyrus, CA1 and CA3 areas of the ...
neurons and muscle fibers differentiated from patient-derived iPSCs revealed that the treatment with rapamycin restores the functionality of motor neurons. Moreover, rapamycin decreases TDP-43 aggregation and apoptosis in these cells (Osaki et al.2018). A different study using mutant OPTN-expressing ...
Preplacodal development begins normally, but placodes arising from the msx expression domain later show elevated apoptosis and are reduced in size. Cell proliferation is normal in these tissues. Unexpectedly, Msx-deficient embryos become ventralized by late gastrulation whereas misexpression of msxB ...
belly spot was noticeable as soon as black pigmentation developed elsewhere and provided a simple visual screen to confirm the PCR genotyping ofMyo10null mice. ~50% ofMyo10tm1d/tm1dmice exhibited webbed digits, a form of syndactyly, with the webbed digits usually affecting the forelimb (Fig....
For instance, CNS-specific type 1 T helper (Th1) cells secrete interferon gamma (IFNγ) following ischemic stroke to recruit immune cells into the CNS [119] and activate cytotoxic CD8+ T cells, which exacerbate CNS damage by inducing apoptosis via caspase activation and Fas ligand signaling [...
neurons and muscle fibers differentiated from patient-derived iPSCs revealed that the treatment with rapamycin restores the functionality of motor neurons. Moreover, rapamycin decreases TDP-43 aggregation and apoptosis in these cells (Osaki et al.2018). A different study using mutant OPTN-expressing ...