Apoptosis (from the Greek apoptosis, i.e., falling of leaves) is the phenomenon of programmed cell death, which plays an important role in the normal embryonic development and maintenance of the homeostasis of the differentiated tissues of adult organisms. Completion of the apoptosis process is ...
life.3 Its rapid degradation by the proteasome has been shown to be required for initiation of the apoptotic cascade in several cell lines.4–7 For a long time, little attention was paid to a potential role for Mcl-1 in the nervous system because initial studies did not detect it in ...
Apoptosis in the nervous system. Apoptosis (from the Greek apoptosis, i.e., falling of leaves) is the phenomenon of programmed cell death, which plays an important role in the normal embry... YA Chelyshev,GV Cherepnev,KI Saitkulov - 《Russian Journal of Developmental Biology》 被引量: ...
Yuan J, Yankner BA (2000) Apoptosis in the nervous system. Nature 407:802–809 CrossRef Akgul C, Edwards SW (2003) Regulation of neutrophil apoptosis via death receptors. Cell Mol Life Sci 60:2402–2408 CrossRef Medema JP, Scaffidi C, Kischkel FC, et al (1997) FLICE is activated ...
To examine in detail neural apoptosis in the central nervous system (CNS) for the establishment of new therapies, we have developed an experimental in vitro model of neuronal death and analyzed the mechanism of apoptosis. Septal nuclei were dissected from embryonic brains (E16) of Wistar rats and...
Up to now,its pathogenesis has not been clarified,and the whole process of central nervous system injury is accompanied by a large number of nerve cell apoptosis,and mitochondria act as cell energy suppliers and metabolic centers. Mitochondria plays an important role in the process of apoptosis. ...
By testing various brain-stem reflexes, moreover, the functions of the brain stem can be assessed clinically with an ease, thoroughness, and degree of detail not possible for any other part of the central nervous system. It must be stressed that the capacity for consciousness (an upper brain...
The studies described above are only a few examples of the involvement of miRNAs in the nervous system. A number of studies have investigated the role of miRNAs in neurological diseases such as epilepsy. Using the pilocarpine mouse model of epilepsy, Nudelman et al. reported that neuronal ...
However, expression of survivin in primary nervous system tumors has not been previously characterized. Immunohistochemistry using anti-human survivin antibody (SURV11-A) was performed on formalin-fixed, paraffin-embedded archival tissue from 112 primary central nervous system tumors. Survivin ...
Apoptosis in the nervous system. Nature 2000; 407: 802–809. 6. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57–70. 7. Kaiser WJ, Vucic D, Miller LK. The Drosophila inhibitor of apoptosis D-IAP1 suppresses cell death induced by the caspase drICE. FEBS Lett ...