dopamine auto-oxidation, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine), to protect against glutamate excitotoxicity, to reduce ischemia-reperfusion injury, to lower neural damage due to gamma-aminolevulinic acid (phorphyria), hyperbaric hyperoxia and a variety of neural toxi...
Central nervous system (CNS) toxicity was first described by Paul Bert in 1877.25o2) of 1.7 atm, below which convulsions do not occur (Table 8-1). The immediate management of an oxygen convulsion is to remove the diver from the oxygen supply. During recompression for a diving...
nervous system (CNS); 4, participate in the formation and functions of the blood-brain barrier; 5, participate in the support of axon tracts of functionally related neurons; 6, monitor for and remove excessive release of neurotransmitters in synapses; 7, protect and insulate nodes of Ranvier; ...
Central nervous system (CNS).The CNS consists of the brain andspinal cord, which occupy the dorsal body cavity and act as the integrating and command centers of the nervous system Peripheral nervous system (PNS).The PNS, the part of the nervous system outside the CNS, consists mainly of th...
They provide significant mechani- cal support and sensory functions, facilitating the trans- port of substances between CSF and parenchyma to maintain the composition of CSF while isolating damag- ing agents to protect the central nervous system (CNS). The apical ciliary clusters of ependymal cells...
Defense against toxins and pathogens Immune response to protect the body Stabilizing body temperature Blood helps regulate body heat Plasma proteins Include albumins, globulins, and fibrinogen Erythrocytes Red blood cells responsible for oxygen transport ...
lactate has been proved to attenuate excitotoxity as a signal molecular by generating ATP and activating PI3-kinase pathway/ KATPchannels via purinergic receptors [103,116]. Besides, lactate has also been reported to protect against neurological damage via receptor GPR81-mediated signaling pathway. ...
Many of these proteins are expressed in the nervous system during development and in the adult. Numerous observations have suggested that this family of proteins plays a central role in the control of naturally occurring and pathological neuronal death. In this review, I will discuss the possible ...
Maturing CNS endothelial cells establish a blood–brain barrier (BBB) to protect the neural tissue from variations in blood composition, to exclude toxins and to maintain ionic homeostasis (reviewed in Engelhardt and Liebner, 2014). To form this barrier, the endothelial cells develop continuous tight...
Neutrophils are crucial mediators of host defense that are recruited to the central nervous system (CNS) in large numbers during acute bacterial meningitis caused by Streptococcus pneumoniae. Neutrophils release neutrophil extracellular traps (NETs) duri