We recently showed that leptin, via its actions on the central nervous system (CNS), improved left ventricular function in a model of heart failure induced by permanent ligation of the left anterior coronary artery (LAD). To investigate whether leptin also protects the heart against ischemia/...
Additional studies are warranted to further characterize hypothalamic Sh2b1 circuits that protect against adipose SNS degeneration. The leptin resistance phenotype of Sh2b1ΔLepR mice supports a concept that Sh2b1 is an endogenous enhancer of leptin sensitivity in vivo. Strikingly, ablation of Sh2b1 ...
lack elaborated brain centers affects them. For instance, immunoreactivity against pCaMKII, a protein enriched in arthropod mushroom bodies, is broadly detected in the larval nervous system of priapulid worms, whose nervous system comprises a simple circumoral nerve ring and a single caudalbipolar ...
However, the ability of endogenous autophagy genes to protect against viral disease in vertebrates remains to be causally established. Here, we report that the autophagy gene Atg5 function is critical for protection against lethal Sindbis virus (SIN) infection of the mouse central nervous system. ...
Your nervous system controls everything from your heartbeat to your emotions. See where the different parts are and what they do with this WebMD slideshow.
However, the ability of endogenous autophagy genes to protect against viral disease in vertebrates remains to be causally established. Here, we report that the autophagy gene Atg5 function is critical for protection against lethal Sindbis virus (SIN) infection of the mouse central nervous system. ...
Glutathione (γ-l-glutamyl-l-cysteinylglycine, GSH) is the most abundant cellular antioxidant molecule in aerobic cells. In the nervous system, it is found in the millimolar range in both neuronal and nonneuronal cells, arising endogenously by synthesis
The pathogenic process in the central nervous system itself should be the major focus in multiple sclerosis therapy in order to protect against demyelination and axonal loss and to promote remyelination and regeneration directly in the target tissue, independently of peripheral immune status. In ...
electrochemical impulses are shooting up and down your nerves as you pause to read this article. Your nervous system is always working. So, make sure you’re doing your part to keep your electrical wiring up to code. There are a couple great ways to support and protect your nervous system...
(BDNF, GDNF, bFGF, IGF1, EGF, NGF) protect against induction of the intrinsic apoptotic cascade via tropomyosin-related receptor kinase (TRK) receptor signaling through PI3K-AKT and MAPK pathways [204,205]. The brain is especially susceptible to oxidative stress given high oxygen demands, high ...