Nerve growth factor (NGF) inhibitors have utilized novel mechanisms different from conventional drugs, which have a variety of gastrointestinal, cardiac, or renal adverse effects. Several phase 2/3 studies have been accomplished for these drugs, such as tanezumab, fasinumab, and tyrosine receptor ...
Inhibition of HCO(3)(-) absorption was reduced 45% by the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin or LY294002 and 50% by rapamycin, a specific inhibitor of mammalian target of rapamycin (mTOR), a downstream effector of PI3K. The combination of a PI3K inhibitor plus ...
2) Epidermal Growth Factor/antagonists and inhibitors 表皮生长因子/拮抗剂和抑制剂3) Endothelial growth factors/antag 内皮生长因子/拮抗剂和抑制剂4) angiogenesis factor/antagonists & inhibitors 血管生因子/拮抗剂和抑制剂5) proton pump/antagonists and inhibitors 质子泵/拮抗剂和抑制剂...
Osteoarthritis (OA) is a painful, incurable disease affecting over 500 million people. Recent clinical trials of the nerve growth factor (NGF) inhibitors in OA patients have suggested adverse effects of NGF inhibition on joint structure. Here we report that nerve growth factor receptor (NGFR) is...
Clinical studies in individuals with painful knee and hip osteoarthritis have revealed that NGF inhibitors substantially reduce joint pain and improve function compared with NSAIDs for a duration of up to 8 weeks. However, the higher tested doses of NGF inhibitors also increased the risk of ...
Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. We have developed an experimental paradigm to study the mechanism by which nerve growth factor (NGF) allows the survival of sympathetic neurons. Dissociate... Martin,D. P. - 《Journal...
Noun1.nerve growth factor- a protein that is involved in the growth of peripheral nerve cells NGF growth factor- a protein that is involved in cell differentiation and growth Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc. ...
Recent clinical trials of the nerve growth factor (NGF) inhibitors in OA patients have suggested adverse effects of NGF inhibition on joint structure. Here we report that nerve growth factor receptor (NGFR) is upregulated in skeletal cells during OA and plays an essential ...
Nerve growth factor inhibitors Nerve growth factor (NGF) is a neurotrophic protein that activates nociceptive neurons to transfer pain signals from the peripheral to the central nervous system. NGF binds to tropomyosin receptor kinase A and the p75 neurotrophin receptors and has an essential role in...
Effects of retinoic acid on proliferation,phenotype and expression of cyclin-dependent kinase inhibitors in TGF-β1-stimulated rat hepatic stellate cells AIM To study the molecular mechanisms ofretinoic acid(RA)on proliferation andexpression of cyclin-dependent kinase inhibitors(CKI),i.e.p16,p21 and ...