We used whole exome sequencing to evaluate the impact of neoantigen ITH and tumor neoantigen burden (TNB) in 45 ICC patients, in which 15 patients were treated by anti-PD1 inhibitor combined with lenvatinib. The median neoantigen and clonal neoantigen load of these patients were 0.65 and 0.29 ...
说的直白点,免疫治疗反应的生物标志物不是MSI,不是dMMR,甚至也不是TMB,而是肿瘤细胞产生的Neoantigen,肿瘤细胞产生的新生抗原则是可以直接评估免疫治疗响应的。 The ultimate biomarker for immunotherapeutic response is not MSI(dMMR) or even the mutational burden (TMB) but the presence of immunogenic neoepitop...
also employed a multi-omics approach combining WES and RNA-seq to assess the neoantigen burden in breast cancer[36]. Their pipeline predicted 434 unique neoantigens from 237 genes, and most of them were patient-specific and MHC class I-specific. Mistretta et al. developed a framework to ...
However, correlation of survival with mutation and neoantigen burden has not been reported for cancers of lower mutational burden such as MM. Early results of single-agent checkpoint inhibitors in MM are underwhelming. Single-agent nivolumab (anti-PD-1 monoclonal antibody) had no objective responses ...
The magnitude of the T cell immune response to cancer typically correlates with neoantigen burden1. However, high tumor heterogeneity and the lack of shared neoepitopes between patients reduces the impact of neoantigen-based therapies as they are challenging to implement and difficult to generalize2. ...
The discovery of neoantigen-specific T cells in cancer patients [1–3] and the observation that mutational burden at the population level was correlated to therapeutic benefit upon checkpoint inhibition has inspired new efforts at developing neoantigen-targeting therapies [4–9]. To this end, case ...
Calculate the tumor neoantigen burden (TNB) metric by either taking the highest score among peptides, or somehow summarize scores of all potent peptides. Use potent peptides to design a vaccine for testing in vitro.ToolsMHC binding prediction methodsMost...
8 Relationship between clonal neoantigen burden, immune infiltration and patient prognosis. a, c, e, Kaplan–Meier curves are shown for lung adenocarcinoma and lung squamous cell carcinoma. The curves are split on the basis of the upper quartile of clonal neoantigen burden (a), on the upper ...
However, these efforts have largely been limited to early-stage/resectable disease, which represents a minority of patients (Ryan et al., 2014), and have primarily focused on missense mutations, which may significantly underestimate the total neoantigen burden in PDAC. To address the broader ...
It outputs a json representation of the clonal structure of the tumor annotated with neoantigen burden, driver burden, and fitness of the clone. Also individual neoantigens are labeled with the quality of the neoantigen as described by Luksza et al. Create phylogenetic trees using PhyloWGS Use ...