62. Coghlan JG, Denton CP, Grünig E, et al. Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Ann Rheum Dis 2014;73:1340-1349. 63. Rengier F, Melzig C, Derlin T, Marra AM, Vogel-Claussen J. Advanced imaging in pulmonary hypertension: ...
62. Coghlan JG, Denton CP, Grünig E, et al. Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Ann Rheum Dis 2014;73:1340-1349. 63. Rengier F, Melzig C, Derlin T, Marra AM, Vogel-Claussen J. Advanced imaging in pulmonary hypertension: ...
20. Collaborative Group on Hormonal Factors in Breast Cancer. Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence. Lancet 2019;394:1159-1168. 21. Brinton LA, Felix AS. Menopausal hormone therapy and ri...
randomized clinical trials, something the field of cardiology widely embraced, years beforeother scientific fields did so. The results of these trials collectively provided definitive evidence that reducing LDL cholesterol levels pre...
Strong evidence has been generated from all five of these sources for both serum anti-spike IgG concentration and anti–SARS-CoV-2 neutralizing antibody titer as CoPs for vaccines against symptomatic Covid-19; for brevity, we focus here...
evidence that reducing LDL cholesterol levels prevents myocardial infarctions, thereby closing the causal loop of Koch’s postulates for the LDL cholesterol hypothesis.1 Thismilestone里程碑, which led to the development of multiple effective cholesterol-lowering drugs, illustrates the power of ...
conference,13withagentsdividedintofouremetogeniclevels(high,moderate,low, andminimal)(Table1).Recentevidence-basedguidelinesforantiemetictreatment reflectacceptanceofthismodifiedschemaasthenewstandardfordefiningthe emetogenicityofintravenouslyadministeredchemotherapeuticagents. Anothercriticalfactorthatledtotherationalevoluti...
and more likely to benefit health than harm. Robust randomised controlled trials are needed to understand whether the observed associations are causal. Importantly, outside of pregnancy, existing evidence suggests that coffee could be tested as an intervention without significant risk of causing harm. ...
ofgovernment.TheCommon-systemperformanceintermsofworkmainlyinprivatepractice, wealthhasresponsibilityforpay-access,improvedquality,andreceivingfee-for-servicepayments ingbenefitsthroughMedicarereasonablecosts.Theseincludethatareanincentivetomaxi- (forout-of-hospitalmedicalcarerequiringevidenceofcost-effec-mizevolumerathe...
spectivestudies17-19indicatethatmostclinicalanddeath,resultinginuncontrolledproliferationof laboratoryfindingsresolveby1monthafterdi-CD8+Tlymphocytes.25 agnosis,butcervicaladenopathyandfatiguemay resolvemoreslowly.Thoughpersistentfatigue(forStrategiesandEvidence 6monthsorlonger)withfunctionalimpairment hasbeendescribed,most...