Anti-‐ SSA/SSB-‐negative Sjogren's syndrome shows a lower prevalence of lymphoproliferative manifestations, and a lower risk of lymphoma evolution. Autoimmunity reviews. 2015; 14(11): 1019-‐22....
Neuromyelitis optica spectrum disorders (NMOSD), a group of autoimmune neurological diseases, involve the optic nerve, spinal cord, and brain. Meningitis is rarely reported as the primary clinical manifestation of both anti-aquaporin-4 (AQP4)/ anti-myeli
negative. Our patient fulfilled the diagnostic criteria of RS3PE syndrome including: 1) pitting edema of the hands and feet; 2) sudden onset of polyarthritis; 3) onset at age 50 years or older; and 4) negative serology for rheumatoid factors [1]. From day 6, she was treated with methy...
Screening for autoimmune disorders and infections has been described,7 and, briefly, it included serum search for antinuclear, anti-double-stranded DNA, anti-SSA/SSB, anti-neutrophil cytoplasmic, anticardiolipin and lupus anticoagulant antibodies; serum/CSF levels of angiotensin- converting enzyme; CSF...
Objective: This study aims to compare clinical and laboratory features of patients who, while satisfying the American European Consensus Group (AECG) criteria for primary Sjogren's syndrome (SS), do not present the positivity for anti-Ro/SSA and/or anti-La/SSB, with patients that meet the ...
Anti-SSAAnti-SSBClinical manifestationInterstitial lung diseaseCurrently, only a few studies have described the general characteristics of patients with primary Sjgren's syndrome (pSS) who tested negatives for anti-SSA and anti-SSB antibodies. We aimed to further investigate the clinical characteristics...
Sjögren'sSyndromeAutoantibodiesSystemicLupusErythematosusObjective To determine whether the Sjögren's syndrome B (SSB)-positive/Sjögren's syndrome A (SSA)-negative antibody profile is associated with key phenotypic features of SS.BMJAnnals of the Rheumatic Diseases...
Dear editor,Here we report a rare case of a patient presented with repeated hypokalemia and metabolic acidosis secondary to primary Sjgren's syndrome(pSS).Though no significantly raised titers of anti-SSA/SSB antibodies was detected in our case,minor salivary gland biopsy,kidney biopsy and ...
Anti-Ro(SSA) and anti-La(SSB) antibodies are found in approximately 25% of systemic lupus erythematosus patients. These antibodies are also detected in lupus patients who fail to demonstrate a significant antinuclear antibody (ANA) titer when mouse liver is employed as the substrate. Approximately...
Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue ResearchBaer AN, McAdams DeMarco M, Shiboski SC, Lam MY, Challacombe S, Daniels TE, et al. The SSB- positive/SSA-negative antibody profile is not associated with key phenotypic features of Sjo篓gren's...