SyndromeAutoantibodiesSystemicLupusErythematosusObjective To determine whether the Sjögren's syndrome B (SSB)-positive/Sjögren's syndrome A (SSA)-negative antibody profile is associated with key phenotypic features of SS.BMJAnnals of the Rheumatic Diseases...
此外,检查抗Ro/SSA抗体(无论有无抗La/SSB抗体)可识别后代新生儿狼疮综合征风险增加的妊娠女性(参见 “新生儿狼疮的流行病学、发病机制、临床表现和诊断”)。抗Ro/SSA抗体还可能是“抗核抗体(antinuclear antibody, ANA)阴性”SLE患者体内唯一的自身抗体。 本文将总结抗Ro/SSA和抗La/SSB抗体系统及这些抗体的临床...
The possible pathological role of antibody subsets specific for different regions of 60-KD and 52-KD Ro/SSA proteins (Ro60 and Ro52) and La protein is uncl... V Ricchiuti,D Isenberg,S Muller - 《Journal of Autoimmunity》 被引量: 60发表: 1994年 Anti-SSA/SSB-negative Sjögren's syndro...
(SLEDAI) than patients with negative anti-SSA60 antibody [(17±9) vs (15±7),t=2.389,P<0.05].Patients positive for anti-SSB antibody had higher level of IgG [(18±7) vs (16±6) g/L,t=2.304,P=0.023],and lower level of CRP than patients negative for anti-SSB antibody [(14±...
The SSB-positive/SSA-negative antibody profile is not associated with key phenotypic features of Sjogren's syndrome. Ann Rheum Dis 2015;74:1557-61.Baer AN, McAdams DeMarco M, Shiboski SC, Lam MY, Challacombe S, Daniels TE, et al. The SSB-positive/SSA-negative antibody profile is not ...
Compared with patients testing positive for anti-SSA or anti-SSB antibodies, that testing negative for the two antibodies had a lower proportion of females (75.3% vs. 90.6%, p<0.001) and thrombocytopenia (6.7% vs. 13.6%, p=0.002), but a higher proportion of abnormal Schirmer I tests (...
Thus, these antibody systems form a serologic link between many unusual connective tissue diseases and systemic SLE.Antibodies to Ro (SSA)-La(SSB) are associated not only with Sjgren's syndrome occurring alone, but also with Sjgren's syndrome occurring in the setting of other connective tissue...
此外,检查抗Ro/SSA抗体(无论有无抗La/SSB抗体)可识别后代新生儿狼疮综合征风险增加的妊娠女性(参见“新生儿狼疮的流行病学、发病机制、临床表现和诊断”)。抗Ro/SSA抗体还可能是“抗核抗体(antinuclear antibody, ANA)阴性”SLE患者体内唯一的自身抗体。
PURPOSE:To measure an antibody by using an antigen for measuring an anti-SSA/Ro or SSB/La antibody, which is manufactured by extracting RNA bound protein from an animal tissue, a culture cell or a processed article thereof and by processing it subsequently by a ribonucleic acid decomposition ...
Background Based on the potential involvement of Toll-like receptor (TLR) signalling in the pathogenesis of neonatal lupus (NL), it was hypothesised that fetal exposure to hydroxychloroquine (HCQ), a TLR inhibitor, might reduce the risk of anti-SSA/Ro/SSB/La antibody-associated cardiac ...