Testosterone may have deleterious effects on cognitive function in older Caucasian men with high oxidative stress (OS), but may be beneficial under conditions of low OS. This is one of the findings of a US study that investigated the relationship between testosterone, OS and cognitive function ...
A \\u00a0-Aminobutyric AcidB Agonist Reverses the Negative Feedback Effect of Testosterone on Gonadotropin-Releasing Hormone and Luteinizing Hormone Secret... Jackson,G.,L. - 《Endocrinology》 被引量: 25发表: 2000年 A gamma-aminobutyric acidB agonist reverses the negative feedback effect of ...
which is a common problem in both men and women of advanced years across the world. According to the creator, this natural remedy takes care of hair growth naturally without and harmful side effects.
Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress (PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead (Pb) ...
Interestingly, however, the success of checkpoint inhibitor therapy that targets PD-L1 does not seem to be dependent on tumor PD-L1 expression6,7,8. To date, precisely how PD-L1 checkpoint pathway inhibitors exert antineoplastic effects in patients without tumor cell PD-L1 expression is not ...
A strong association between biologically active testosterone and leptin in non-obese men and women is lost with increasing (central) adiposity. OBJECTIVE: In both humans and rodents, males have lower levels of leptin than females at any level of adiposity. Experimental data support the idea that...
The beneficial effects of tamoxifen treatment in ER+ patients remained regardless of AR status. And although an improvement in breast cancer-specific survival was seen in the current cohort, the AR− group had a similar trend, and the interaction test was not significant. In a previous study,...
Polychlorinated biphenyls (PCBs) and per- and polyfluoroalkyl substances (PFAS) are two of the main classes of POPs associated with disturbances in different human systems, mainly the nervous and endocrine systems. This narrative review discusses the main PCB and PFAS effects on the CNS, focusing...
During early pregnancy, concentrations of testosterone and IGF-1 are largely similar to prepregnancy concentrations. "We found that circulating concentrations of IGF-1 and testosterone are directly associated with risk for HR-positive breast cancer, in line with studies in nonpregnant women," Luka...
being relatively sudden and dramatic in the case of estrogen in women, but more gradual and steady for testosterone in men, and GH in both genders [203–207]. Indeed, circulating GH levels decline progressively after 30 years of age at a rate of ∼1% per year [203]. In addition, ther...