Inhibition of neddylation pathway represses influ- enza virus replication and pro-inflammatory responses. Virology. 2018; 514: 230-239. https://doi.org/ 10.1016/j.virol.2017.11.004 PMID: 29248752Inhibition of neddylation pathway represses influenza virus replication and pro-inflammatory responses. Sun ...
Jia, Neddylation pathway as a novel anti-cancer target: mech- anistic investigation and therapeutic implication, Anticancer Agents Med. Chem. 9 (2015) 1127e1133.Jiang Y, Jia L. Neddylation pathway as a novel anti-cancer target: mech- anistic investigation and therapeutic implication. Anticancer ...
Targeting Neddylation pathway plays an anti-tumor role by inducing cell cycle arrest, apoptosis, senescence and autophagy of digestive system tumor cells, as well as enhancing the sensitivity of digestive system tumor cells to the radiotherapy and chemotherapy. Targeting Neddylation pathway and its ...
Inhibition of neddylation pathway has emerged as a promising anticancer strategy, as evidenced by development of the NEDD8-activating enzyme (NAE) inhibitor MLN4924. Due to its potent anti-cancer efficacy and well-tolerated toxicity, MLN4924 has been evaluated in multiple Phase I clinical trials for...
内容提示: 1 Protein neddylation pathway in Trypanosoma brucei: functional characterization and substrate identification Shanhui Liao 1, 2, Huiqing Hu 2 , Tao Wang 2, # , Xiaoming Tu 1, *, and Ziyin Li 2, * 1 Hefei National Laboratory for Physical Sciences at Microscale, School of Life ...
The neddylation pathway.aThree enzymes catalyze the NEDD8 attachment to a substrate: E1 activation enzyme, a heterodimer of catalytic subunit UBA3/NAEβ, and regulatory subunit NAE1/APPBP1; E2 conjugation enzymes, UBE2M/UBC12 and UBE2F; and E3 ligases (e.g., RBX1 and RBX2). One type of...
[5] LI L H, WANG M S, YU G Y, et al. Overactivated neddylation pathway as a therapeutic target in lung cancer[J]. J Natl Cancer Inst, 2014, 106(6): dju083. [6] LUO Z G, YU G Y, LEE H W, et al...
Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling Jin HS, Liao L, Park Y, Liu YC: Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling... ...
Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling — T-cell regulation by neddylation —... 被引量: 0发表: 0年来源期刊 Pnas 研究点推荐 protein neddylation NEDD8 Neddylation pathway 引用走势 2014 被引量:27 站内活动 ...
The neddylation pathway.aThree enzymes catalyze the NEDD8 attachment to a substrate: E1 activation enzyme, a heterodimer of catalytic subunit UBA3/NAEβ, and regulatory subunit NAE1/APPBP1; E2 conjugation enzymes, UBE2M/UBC12 and UBE2F; and E3 ligases (e.g., RBX1 and RBX2). One type of...